Tanshinone IIA inhibits gastric cancer cell stemness through inducing ferroptosis.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental toxicology"
DOI: 10.1002/tox.23388
Abstract: Tanshinone IIA is the active constituent extracted from Salvia Miltiorrhza. Numerous studies have shown that Tanshinone IIA could inhibit tumor proliferation and metastasis, including gastric cancer. However, the effect of Tanshinone IIA on gastric cancer… read more here.
Keywords: gastric cancer; iia; cell stemness; tanshinone iia ... See more keywords
Tanshinone IIA prevents acetaminophen‐induced nephrotoxicity through the activation of the Nrf2‐Mrp2/4 pathway in mice
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23511
Abstract: It's known that APAP overdose often leads to hepatotoxicity and nephrotoxicity. In the present study, we investigated the preventative effect of Tan IIA on APAP‐induced nephrotoxicity. Mice were orally administrated with Tan IIA (10 or… read more here.
Keywords: nrf2 mrp2; iia; tan iia; mice ... See more keywords
Tanshinone IIA pretreatment promotes cell survival in human lung epithelial cells under hypoxia via AP-1-Nrf2 transcription factor
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01083-3
Abstract: Activator protein-1 (AP-1) plays a decisive role in cell proliferation, apoptosis, and inflammation under hypoxia; thus, AP-1 subunits or dimers could be modulated for a desired phenomenon in a cell using a suitable compound of… read more here.
Keywords: nrf2 transcription; cell survival; tan iia; tanshinone iia ... See more keywords
Tanshinone IIa protects retinal endothelial cells against mitochondrial fission induced by methylglyoxal through glyoxalase 1.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172419
Abstract: Advanced glycation end products (AGEs) play an important role in the onset of diabetic retinopathy. Therefore, in the current study, we investigate whether and how Tanshinone IIa (Tan IIa) from Salvia miltiorrhiza protects bovine retinal… read more here.
Keywords: mgo; tan iia; mitochondrial fission; iia ... See more keywords
Dual-source computed tomography for quantitative assessment of tracheobronchial anomaly from type IIA pulmonary artery sling in pediatric patients.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2018.02.030
Abstract: PURPOSE As an extremely rare abnormity, type IIA pulmonary artery sling (PAS) tracheobronchial anomalies should be differentiated from normal airway for therapeutic decision-making. This study aimed to investigate the quantitative characteristics of type IIA PAS… read more here.
Keywords: type iia; iia; iia pulmonary; iia pas ... See more keywords
RasGRF1 participates in the protective effect of tanshinone IIA on depressive like behaviors of a chronic unpredictable mild stress induced mouse model.
Sign Up to like & getrecommendations! Published in 2020 at "Gene"
DOI: 10.1016/j.gene.2020.144817
Abstract: Tanshinone IIA (Tan IIA) is reported to have neuroprotective effects to suppress cell apoptosis of cortical neurons induced by Aβ25-35 through inhibiting oxidative stress. Nevertheless, few studies have investigated the effects of Tan IIA on… read more here.
Keywords: tan iia; tanshinone iia; like behaviors; stress ... See more keywords
Distinguishing septic from normal donors by detection of sPLA2-IIA from human plasma using a microsieve-based immunoassay.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2017.04.007
Abstract: Bloodstream infections that progress to septic shock are responsible for hundreds of thousands of deaths each year, and are associated with significant healthcare costs. Recent studies have shown that a member of the secreted phospholipase… read more here.
Keywords: plasma; microsieve based; iia; microsieve assay ... See more keywords
Outcomes of balloon-expandable versus self-expandable stent-graft for endovascular repair of iliac aneurysms using iliac branch endoprosthesis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of vascular surgery"
DOI: 10.1016/j.jvs.2021.10.022
Abstract: PURPOSE The purpose of this study was to compare outcomes of internal iliac artery (IIA) stenting using balloon-expandable (BESG) or self-expandable stent-grafts (SESG) during endovascular repair of aortoiliac aneurysms with iliac branch endoprosthesis (IBE, WL… read more here.
Keywords: branch; freedom; iia; besg sesg ... See more keywords
Oleanolic acid protects against cognitive decline and neuroinflammation‐mediated neurotoxicity by blocking secretory phospholipase A2 IIA‐activated calcium signals
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.04.015
Abstract: HIGHLIGHTSOleanolic acid suppresses inflammatory response in A&bgr;‐activated astrocyte.OA attenuates A&bgr;‐stimulated astrocytes‐induced neuronal growth inhibition.OA restrains A&bgr;‐induced expression and release of sPLA2‐IIA.OA protects against A&bgr;‐induced neurotoxicity by blocking sPLA2‐IIA‐evoked Ca2+ influx.OA ameliorates cognitive deficits and inflammatory… read more here.
Keywords: bgr activated; neurotoxicity; acid; iia ... See more keywords
Prospective therapeutic potential of Tanshinone IIA: An updated overview.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105364
Abstract: In the past decades, the branch of complementary and alternative medicine based therapeutics has gained considerable attention worldwide. Pharmacological efficacy of various traditional medicinal plants, their products and/or product derivatives have been explored on an… read more here.
Keywords: medicine; tan iia; tanshinone iia; therapeutic potential ... See more keywords
Binary amorphous solids consisting of 2,4,6-triarylphenoxyl radicals and their dimers
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.05.040
Abstract: Abstract Although molecular amorphous materials represent an important area of research in solid-state chemistry, studies pertaining to these systems have been restricted almost exclusively to amorphous solids based on a single molecule. In this study,… read more here.
Keywords: binary amorphous; consisting triarylphenoxyl; amorphous solids; solids consisting ... See more keywords