Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104433
Abstract: The G-quadruplex (G4) DNA, which has been developed as a potential anticancer target in drug screening and design, plays a crucial role in the oncogene transcription and translation. Tanshinone IIA derivatives with a planar heterocycle… read more here.
Keywords: iia derivatives; quadruplex dna; tanshinone iia;
Continuous synthesis and anti-myocardial injury of tanshinone IIA derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2017.1337751
Abstract: Abstract A series of tanshinone IIA derivatives were synthesized through sulfonation, slat-forming, chlorination, and amidation reactions. Meanwhile, anti-myocardial injury activity was evaluated in vitro. D8 and D9 exhibited a slightly higher anti-myocardial injury (5.78, 7.46… read more here.
Keywords: iia derivatives; anti myocardial; myocardial injury; tanshinone iia ... See more keywords