Maximum Emission Peak Over 1500 nm of Organic Assembly for Blood–Brain Barrier‐Crossing NIR‐IIb Phototheranostics of Orthotopic Glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202208097
Abstract: The development of blood–brain barrier (BBB)‐crossing phototheranostic agents in second near‐infrared window (NIR‐II), especially in the range of 1500–1700 nm (NIR‐IIb), affords great opportunities for glioblastoma (GBM) management. Herein, an organic assembly (denoted as LET‐12)… read more here.
Keywords: iib phototheranostics; blood brain; peak; nir iib ... See more keywords
In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.365
Abstract: Studies on the inherited bleeding disorder, Glanzmann thrombasthenia (GT), have helped define the role of the αIIbβ3 integrin in platelet aggregation. Stable bent αIIbβ3 undergoes conformation changes on activation allowing fibrinogen binding and its taking… read more here.
Keywords: glanzmann thrombasthenia; silico analysis; iib genu; iib ... See more keywords
Differential Expression Hallmarks of Interneurons in Different Types of Focal Cortical Dysplasia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-020-01492-0
Abstract: Focal cortical dysplasia (FCD) is the main cause of medically intractable pediatric epilepsy. Previous studies have suggested that alteration of cortical interneurons and abnormal cytoarchitecture have been linked to initiation and development for seizure. However,… read more here.
Keywords: type iib; focal cortical; fcd type; vip ... See more keywords
A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c11706
Abstract: Near-infrared window IIb (NIR-IIb, 1500-1700 nm) fluorescence imaging demonstrates attractive properties including low scattering, low absorption, and deep tissue penetration, and photothermal therapy (PTT) is also a promising modality for cancer treatment. However, until now,… read more here.
Keywords: near infrared; iib imaging; tqf; tumor ... See more keywords
Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86874-z
Abstract: Absorption of dietary phosphate (Pi) across intestinal epithelia is a regulated process mediated by transcellular and paracellular pathways. Although hyperphosphatemia is a risk factor for the development of cardiovascular disease, the amount of ingested Pi… read more here.
Keywords: absorption; constitutive depletion; depletion slc34a2; napi iib ... See more keywords
Near-infrared -triggered release of tirofiban from nanocarriers for the inhibition of platelet integrin αIIbβ3 to decrease early-stage neointima formation.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr00555j
Abstract: Platelets play an important role in the early stage of arterial remodeling after injury. Integrin GPIIb/IIIα (αIIbβ3) regulates platelet activation in the inside-out and outside-in signaling pathways. The use of tirofiban, an integrin αIIbβ3 inhibitor,… read more here.
Keywords: neointima formation; integrin iib; platelet; iib ... See more keywords
Near-infrared-IIb probe affords ultrahigh contrast inflammation imaging
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra06249a
Abstract: Deep tissue imaging in the near-infrared II (NIR-II) window with significantly reduced tissue autofluorescence and scattering provides an important modality to visualize various biological events. Current commercially used contrast agents in the near-infrared spectrum suffer… read more here.
Keywords: contrast; probe; near infrared; inflammation ... See more keywords
SN2017jgh: a high-cadence complete shock cooling light curve of a SN IIb with the Kepler telescope
Sign Up to like & getrecommendations! Published in 2021 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnras/stab2138
Abstract: SN 2017jgh is a type IIb supernova discovered by Pan-STARRS during the C16/C17 campaigns of the Kepler/K2 mission. Here, we present the Kepler/K2 and ground based observations of SN 2017jgh, which captured the shock cooling of the… read more here.
Keywords: light curve; kepler; shock cooling; shock ... See more keywords
Active Calpain Promotes Fibrin Clot Contraction By Strengthening the Coupling of Fibrin-Bound αIIbβ3 to the Platelet Cytoskeleton
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-113063
Abstract: Platelet-driven blood clot contraction reduces and compacts clot volume, promoting hemostasis while restoring blood flow past otherwise obstructive thrombi. Clot contraction is driven by traction forces in the range of tens of pN per platelet… read more here.
Keywords: calpain; contraction; clot contraction; platelet ... See more keywords
A Single F153Sβ3 Mutation Causes Constitutive Integrin αIIbβ3 Activation in a Variant Form of Glanzmann Thrombasthenia.
Sign Up to like & getrecommendations! Published in 2023 at "Blood advances"
DOI: 10.1182/bloodadvances.2022009495
Abstract: This report identifies a novel variant form of the inherited bleeding disorder, Glanzmann thrombasthenia (GT) exhibiting only mild bleeding in a physically active individual. The platelets cannot aggregate ex vivo with physiologic agonists of activation,… read more here.
Keywords: variant form; iib activation; glanzmann thrombasthenia; single f153s ... See more keywords
Binding of CIB1 to the αIIb tail of αIIbβ3 is required for FAK recruitment and activation in platelets
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0176602
Abstract: Background It is believed that activation of c-Src bound to the integrin β3 subunit initiates outside-in signaling. The involvement of αIIb in outside-in signaling is poorly understood. Objectives We have previously shown that CIB1 specifically… read more here.
Keywords: iib required; cib1 iib; outside signaling; activation ... See more keywords