Selective Twin NIR‐IIb Ratiometric Luminescence Nanoprobes Enable the Accurate Visualization of MPO‐Mediated Oxidative Stress in Acute Liver Injury
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202414772
Abstract: Oxidative stress, orchestrated by myeloperoxidase (MPO), plays crucial roles in the progression of many diseases. Nonetheless, the role of MPO‐mediated oxidative stress in distinct factor‐induced acute liver injuries (ALI) is still up for dispute, mainly… read more here.
Keywords: mediated oxidative; mpo mediated; oxidative stress; iib ... See more keywords
Maximum Emission Peak Over 1500 nm of Organic Assembly for Blood–Brain Barrier‐Crossing NIR‐IIb Phototheranostics of Orthotopic Glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202208097
Abstract: The development of blood–brain barrier (BBB)‐crossing phototheranostic agents in second near‐infrared window (NIR‐II), especially in the range of 1500–1700 nm (NIR‐IIb), affords great opportunities for glioblastoma (GBM) management. Herein, an organic assembly (denoted as LET‐12)… read more here.
Keywords: iib phototheranostics; blood brain; peak; nir iib ... See more keywords
Dysregulation of Myelination in Focal Cortical Dysplasia Type II of the Human Frontal Lobe
Sign Up to like & getrecommendations! Published in 2024 at "Glia"
DOI: 10.1002/glia.24662
Abstract: Focal cortical dysplasias (FCDs) are local malformations of the human neocortex and a leading cause of intractable epilepsy. FCDs are classified into different subtypes including FCD IIa and IIb, characterized by a blurred gray‐white matter… read more here.
Keywords: fcd iia; myelination; frontal lobe; iib ... See more keywords
In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.365
Abstract: Studies on the inherited bleeding disorder, Glanzmann thrombasthenia (GT), have helped define the role of the αIIbβ3 integrin in platelet aggregation. Stable bent αIIbβ3 undergoes conformation changes on activation allowing fibrinogen binding and its taking… read more here.
Keywords: glanzmann thrombasthenia; silico analysis; iib genu; iib ... See more keywords
Differential Expression Hallmarks of Interneurons in Different Types of Focal Cortical Dysplasia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Neuroscience"
DOI: 10.1007/s12031-020-01492-0
Abstract: Focal cortical dysplasia (FCD) is the main cause of medically intractable pediatric epilepsy. Previous studies have suggested that alteration of cortical interneurons and abnormal cytoarchitecture have been linked to initiation and development for seizure. However,… read more here.
Keywords: type iib; focal cortical; fcd type; vip ... See more keywords
Visualization of Diabetes Progression by an Activatable NIR-IIb Luminescent Probe.
Sign Up to like & getrecommendations! Published in 2024 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.4c02629
Abstract: Developing NIR-IIb luminescence probes with rapid visualization and a high penetration depth is essential for diabetes research. Combining a sensitizing switch with lanthanide-doped nanoparticles (LnNPs) has been employed to fabricate the NIR-IIb probes. However, these… read more here.
Keywords: visualization; nir iib; iib probes; iib ... See more keywords
A Small-Molecule Based Organic Nanoparticle for Photothermal Therapy and Near-Infrared-IIb Imaging.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c11706
Abstract: Near-infrared window IIb (NIR-IIb, 1500-1700 nm) fluorescence imaging demonstrates attractive properties including low scattering, low absorption, and deep tissue penetration, and photothermal therapy (PTT) is also a promising modality for cancer treatment. However, until now,… read more here.
Keywords: near infrared; iib imaging; tqf; tumor ... See more keywords
Platelet integrin αIIbβ3 plays a key role in a venous thrombogenesis mouse model
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52869-3
Abstract: Venous thrombosis (VT) is a common vascular disease associated with reduced survival and a high recurrence rate. VT is initiated by the accumulation of platelets and neutrophils at sites of endothelial cell activation. A role… read more here.
Keywords: role; venous thrombogenesis; platelet; tirofiban ... See more keywords
Constitutive depletion of Slc34a2/NaPi-IIb in rats causes perinatal mortality
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86874-z
Abstract: Absorption of dietary phosphate (Pi) across intestinal epithelia is a regulated process mediated by transcellular and paracellular pathways. Although hyperphosphatemia is a risk factor for the development of cardiovascular disease, the amount of ingested Pi… read more here.
Keywords: absorption; constitutive depletion; depletion slc34a2; napi iib ... See more keywords
Near-infrared -triggered release of tirofiban from nanocarriers for the inhibition of platelet integrin αIIbβ3 to decrease early-stage neointima formation.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr00555j
Abstract: Platelets play an important role in the early stage of arterial remodeling after injury. Integrin GPIIb/IIIα (αIIbβ3) regulates platelet activation in the inside-out and outside-in signaling pathways. The use of tirofiban, an integrin αIIbβ3 inhibitor,… read more here.
Keywords: neointima formation; integrin iib; platelet; iib ... See more keywords
Near-infrared-IIb probe affords ultrahigh contrast inflammation imaging
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra06249a
Abstract: Deep tissue imaging in the near-infrared II (NIR-II) window with significantly reduced tissue autofluorescence and scattering provides an important modality to visualize various biological events. Current commercially used contrast agents in the near-infrared spectrum suffer… read more here.
Keywords: contrast; probe; near infrared; inflammation ... See more keywords