Role of Deficient DNA Mismatch Repair Status in Patients With Stage III Colon Cancer Treated With FOLFOX Adjuvant Chemotherapy: A Pooled Analysis From 2 Randomized Clinical Trials
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.2899
Abstract: Importance The prognostic impact of DNA mismatch repair (MMR) status in stage III colon cancer patients receiving FOLFOX (folinic acid, fluorouracil, and oxaliplatin) adjuvant chemotherapy remains controversial. Objective To determine the association of MMR status… read more here.
Keywords: status; stage iii; iii colon; colon cancer ... See more keywords
Comparing Trial and Real-world Adjuvant Oxaliplatin Delivery in Patients With Stage III Colon Cancer Using a Longitudinal Cumulative Dose.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.4445
Abstract: Importance Delivery of adjuvant chemotherapy can differ substantially between trial and real-world populations. Adherence metrics like relative dose intensity (RDI) cannot capture the timing of modifications and mask differences in the total amount of chemotherapy… read more here.
Keywords: oncology; trial; stage iii; colon cancer ... See more keywords
Some stage III colon cancer patients may need only half of the standard chemotherapy course
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.31042
Abstract: 3871 Content in this section does not reflect any official policy or medical opinion of the American Cancer Society or of the publisher unless otherwise noted. © American Cancer Society, 2017. • The rate at… read more here.
Keywords: project; stage iii; iii colon; project genie ... See more keywords
Longitudinal effects of adjuvant chemotherapy and related neuropathy on health utility in stage II and III colon cancer patients: A prospective cohort study
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Cancer"
DOI: 10.1002/ijc.33472
Abstract: Patient's quality of life should be included in clinical decision making regarding the administration of adjuvant chemotherapy (ACT) in stage II/III colon cancer. Therefore, quality of life, summarized as health utility (HU), was evaluated for… read more here.
Keywords: stage iii; patients treated; act; iii colon ... See more keywords
What We Know About Stage II and III Colon Cancer: It’s Still Not Enough
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DOI: 10.1007/s11523-017-0494-5
Abstract: The introduction of oxaliplatin as adjuvant treatment for stage III colon cancer in 2004 has been the last practice changing progress in adjuvant treatment for patients with early colon cancer. Since then, many prognostic and… read more here.
Keywords: colon cancer; stage iii; iii colon; colon ... See more keywords
S-1 and oxaliplatin versus tegafur-uracil and leucovorin as post-operative adjuvant chemotherapy in patients with high-risk stage III colon cancer: updated 5-year survival of the phase III ACTS-CC 02 trial
Sign Up to like & getrecommendations! Published in 2021 at "ESMO Open"
DOI: 10.1016/j.esmoop.2021.100077
Abstract: Background The ACTS-CC 02 trial demonstrated that S-1 plus oxaliplatin (SOX) was not superior to tegafur-uracil and leucovorin (UFT/LV) in terms of disease-free survival (DFS) as adjuvant chemotherapy for high-risk stage III colon cancer (any… read more here.
Keywords: stage iii; high risk; risk stage; year ... See more keywords
The use of chemotherapy in older patients with stage II and III colon cancer: Variation by age and era of diagnosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of geriatric oncology"
DOI: 10.1016/j.jgo.2018.07.012
Abstract: OBJECTIVE We aim to examine the use and outcomes of adjuvant chemotherapy in older patients with stage II and III colon cancer. MATERIAL AND METHODS Using data from the SEER-Medicare database, we analyzed patients aged… read more here.
Keywords: chemotherapy; stage iii; adjuvant chemotherapy; age ... See more keywords
Analysis of relapse-associated alternative mRNA splicing and construction of a prognostic signature predicting relapse in I-III colon cancer.
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DOI: 10.1016/j.ygeno.2020.07.002
Abstract: The literature comprehensively analyzed alternative splicing (AS) events in colon cancer is little and corresponding prognostic signature is still a lack. Based on data of TCGA, the relapse-associated ASs were comprehensively analyzed and a signature… read more here.
Keywords: relapse; colon cancer; iii colon; signature ... See more keywords
Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer
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DOI: 10.1038/s41416-019-0519-1
Abstract: BackgroundIdentification of biomarkers associated with benefit of adjuvant chemotherapy in stage II/III colon cancer is an important task.MethodsVessel density (VD) and tumour stroma were analysed in a randomised-trial-derived discovery cohort (n = 312) and in a stage… read more here.
Keywords: stage iii; stroma normalised; iii colon; stroma ... See more keywords
Novel and Simple Nomograms Using Inflammation and Nutritional Biomarkers for Stage II-III Colon Cancer, Taking "Time after Curative Surgery" into Consideration.
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition and cancer"
DOI: 10.1080/01635581.2022.2042570
Abstract: PURPOSE Recurrence of colon cancer is associated with time after curative surgery. This study aimed to construct novel nomograms to predict relapse-free survival (RFS) in stage II-III colon cancer, considering "time after surgery" and using… read more here.
Keywords: stage iii; time; cancer; colon cancer ... See more keywords
Administration of adjuvant chemotherapy in older patients with Stage III colon cancer: an observational study
Sign Up to like & getrecommendations! Published in 2017 at "Colorectal Disease"
DOI: 10.1111/codi.13876
Abstract: According to established guidelines, patients with Stage III colon cancer should receive adjuvant chemotherapy. However, a significant proportion do not. This study assessed factors associated with the administration of adjuvant chemotherapy and causes of death. read more here.
Keywords: chemotherapy; stage iii; adjuvant chemotherapy; iii colon ... See more keywords