A peroxodiiron(III) intermediate mediating both N-hydroxylation steps in biosynthesis of the N-nitrosourea pharmacophore of streptozotocin by SznF.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c03431
Abstract: The alkylating warhead of the antineoplastic drug streptozotocin (SZN) contains an N-nitrosourea moiety constructed from Nω-methyl-L-arginine (L-NMA) by the multi-domain metalloenzyme SznF. The enzyme's central heme-oxygenase-like (HO-like) domain sequentially hydroxylates Nδ and Nω' of L-NMA.… read more here.
Keywords: iii; sznf; iii intermediate; hydroxylation steps ... See more keywords
Noise-induced hearing loss vulnerability in type III intermediate filament peripherin gene knockout mice
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DOI: 10.3389/fneur.2022.962227
Abstract: In the post-natal mouse cochlea, type II spiral ganglion neurons (SGNs) innervating the electromotile outer hair cells (OHCs) of the ‘cochlear amplifier' selectively express the type III intermediate filament peripherin gene (Prph). Immunolabeling showed that… read more here.
Keywords: filament peripherin; type; type iii; iii intermediate ... See more keywords
The Type III Intermediate Filament Protein Peripherin Regulates Lysosomal Degradation Activity and Autophagy
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DOI: 10.3390/ijms26020549
Abstract: Peripherin belongs to heterogeneous class III of intermediate filaments, and it is the only intermediate filament protein selectively expressed in the neurons of the peripheral nervous system. It has been previously discovered that peripherin interacts… read more here.
Keywords: iii intermediate; peripherin; degradation; filament protein ... See more keywords