A peroxodiiron(III) intermediate mediating both N-hydroxylation steps in biosynthesis of the N-nitrosourea pharmacophore of streptozotocin by SznF.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c03431
Abstract: The alkylating warhead of the antineoplastic drug streptozotocin (SZN) contains an N-nitrosourea moiety constructed from Nω-methyl-L-arginine (L-NMA) by the multi-domain metalloenzyme SznF. The enzyme's central heme-oxygenase-like (HO-like) domain sequentially hydroxylates Nδ and Nω' of L-NMA.… read more here.
Keywords: iii; sznf; iii intermediate; hydroxylation steps ... See more keywords
Noise-induced hearing loss vulnerability in type III intermediate filament peripherin gene knockout mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.962227
Abstract: In the post-natal mouse cochlea, type II spiral ganglion neurons (SGNs) innervating the electromotile outer hair cells (OHCs) of the ‘cochlear amplifier' selectively express the type III intermediate filament peripherin gene (Prph). Immunolabeling showed that… read more here.
Keywords: filament peripherin; type; type iii; iii intermediate ... See more keywords