Effect of acute kidney injury and overall survival in patients with postoperative head and neck cancer who received chemoradiotherapy with cisplatin: A supplementary analysis of the phase II/III trial of JCOG1008
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70235
Abstract: In a randomized phase II/III trial (JCOG1008), weekly cisplatin (40 mg/m2) was non‐inferior to 3‐weekly cisplatin (100 mg/m2) for postoperative high‐risk head and neck cancer. We investigated how acute kidney injury (AKI), a major dose‐limiting toxicity effect… read more here.
Keywords: phase iii; cancer; cisplatin; head neck ... See more keywords
Phase III Trial of Intravenous Mannitol Versus Placebo During Nephron-sparing Surgery: Post Hoc Analysis of 3-yr Outcomes.
Sign Up to like & getrecommendations! Published in 2019 at "European urology focus"
DOI: 10.1016/j.euf.2019.04.003
Abstract: Our recently reported phase III trial demonstrated that patients undergoing nephron-sparing surgery (NSS) with an estimated glomerular filtration rate (eGFR) of ≥45 ml/min/1.73 m2 who received mannitol had no improvement in renal function at 6 mo… read more here.
Keywords: surgery; trial; nephron sparing; mannitol ... See more keywords
Who Benefits From a Prostate Rectal Spacer? Secondary Analysis of a Phase III Trial.
Sign Up to like & getrecommendations! Published in 2020 at "Practical radiation oncology"
DOI: 10.1016/j.prro.2019.12.011
Abstract: PURPOSE/OBJECTIVE(S) Previously a phase III trial of a hydrogel rectal spacer during prostate RT found decreased toxicity and a clinically significant improvement in bowel quality of life (QOL) at 3-years by Expanded Prostate Cancer Index… read more here.
Keywords: rectal spacer; trial; spacer; iii trial ... See more keywords
Long-term abatacept treatment for 48 weeks in patients with primary Sjögren's syndrome: The open-label extension phase of the ASAP-III trial.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2022.151955
Abstract: OBJECTIVE To investigate treatment efficacy of long-term abatacept treatment in pSS patients. METHODS The single-centre ASAP-III trial consisted of two phases: the randomised, double-blind, placebo-controlled phase (1:1 randomisation) from baseline to week 24, of which… read more here.
Keywords: abatacept treatment; iii trial; long term; treatment ... See more keywords
Impact of a quadrivalent inactivated influenza vaccine on influenza-associated complications and health care use in children aged 6 to 35 months: Analysis of data from a phase III trial in the Northern and Southern Hemispheres.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.01.059
Abstract: BACKGROUND A multi-season phase III trial conducted in the Northern and Southern Hemispheres demonstrated the efficacy of a quadrivalent split-virion inactivated influenza vaccine (IIV4) in children 6-35 months of age. METHODS Data collected during the phase… read more here.
Keywords: trial; children aged; iii trial; phase iii ... See more keywords
Randomized phase III trial of post-operative chemotherapy for patients with stage I/II/III small bowel adenocarcinoma (JCOG1502C, J-BALLAD).
Sign Up to like & getrecommendations! Published in 2018 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyy188
Abstract: A randomized phase III trial was initiated in May 2017 to confirm the superiority of post-operative therapy with capecitabine and oxaliplatin over observation in terms of relapse-free survival in patients with curatively resected small bowel… read more here.
Keywords: small bowel; trial; iii trial; phase iii ... See more keywords
Savolitinib Heads for Phase III Trial in PRCC.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2017-105
Abstract: A phase II trial of savolitinib, a MET inhibitor, found that the drug induced partial responses in some patients with papillary renal cell carcinoma and was well tolerated, prompting drug makers Chi-Med and AstraZeneca to… read more here.
Keywords: trial; savolitinib heads; heads phase; iii trial ... See more keywords
A randomized phase III trial on the role of esophagectomy in complete responders to preoperative chemoradiotherapy (CRT) for esophageal squamous cell carcinoma (ESCC).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.4020
Abstract: 4020Background: To investigate the role of esophagectomy in pts who achieved clinical complete response (cCR) with CRT for locally advanced ESCC. Methods: Pts with resectable cT3-T4a anyN M0 or any... read more here.
Keywords: role esophagectomy; iii trial; randomized phase; phase iii ... See more keywords
Dacomitinib versus gefitinib for the first-line treatment of advanced EGFR mutation positive non-small cell lung cancer (ARCHER 1050): A randomized, open-label phase III trial.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.18_suppl.lba9007
Abstract: LBA9007Background: Dacomitinib is a 2nd generation EGFR TKI with encouraging clinical activity as 1st-line therapy in patients with EGFR-activating mutation positive advanced NSCLC (Janne, Lancet Oncol 2014). We performed the first randomized phase III trial,… read more here.
Keywords: egfr mutation; line; mutation positive; iii trial ... See more keywords
CTONG1104: Adjuvant gefitinib versus chemotherapy for resected N1-N2 NSCLC with EGFR mutation—Final overall survival analysis of the randomized phase III trial 1 analysis of the randomized phase III trial.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.9005
Abstract: 9005Background: ADJUVANT-CTONG1104, a randomized phase 3 trial showed adjuvant gefitinib treatment significantly improved disease-free survival (DFS) vs standard doublet chemotherapy in patients (p... read more here.
Keywords: phase; iii trial; randomized phase; phase iii ... See more keywords
A phase III trial of docetaxel versus docetaxel and radium-223 (Ra-223) in patients with metastatic castration-resistant prostate cancer (mCRPC): DORA.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.tps5594
Abstract: TPS348Background: Ra-223, a bone-targeted alpha therapy, is a well-tolerated treatment option that prolongs survival in patients (pts) with symptomatic mCRPC to bone. Docetaxel targets microtubule ... read more here.
Keywords: phase iii; mcrpc; docetaxel versus; docetaxel ... See more keywords