Phase III Trial of Intravenous Mannitol Versus Placebo During Nephron-sparing Surgery: Post Hoc Analysis of 3-yr Outcomes.
Sign Up to like & getrecommendations! Published in 2019 at "European urology focus"
DOI: 10.1016/j.euf.2019.04.003
Abstract: Our recently reported phase III trial demonstrated that patients undergoing nephron-sparing surgery (NSS) with an estimated glomerular filtration rate (eGFR) of ≥45 ml/min/1.73 m2 who received mannitol had no improvement in renal function at 6 mo… read more here.
Keywords: surgery; trial; nephron sparing; mannitol ... See more keywords
Who Benefits From a Prostate Rectal Spacer? Secondary Analysis of a Phase III Trial.
Sign Up to like & getrecommendations! Published in 2020 at "Practical radiation oncology"
DOI: 10.1016/j.prro.2019.12.011
Abstract: PURPOSE/OBJECTIVE(S) Previously a phase III trial of a hydrogel rectal spacer during prostate RT found decreased toxicity and a clinically significant improvement in bowel quality of life (QOL) at 3-years by Expanded Prostate Cancer Index… read more here.
Keywords: rectal spacer; trial; spacer; iii trial ... See more keywords
Long-term abatacept treatment for 48 weeks in patients with primary Sjögren's syndrome: The open-label extension phase of the ASAP-III trial.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2022.151955
Abstract: OBJECTIVE To investigate treatment efficacy of long-term abatacept treatment in pSS patients. METHODS The single-centre ASAP-III trial consisted of two phases: the randomised, double-blind, placebo-controlled phase (1:1 randomisation) from baseline to week 24, of which… read more here.
Keywords: abatacept treatment; iii trial; long term; treatment ... See more keywords
Impact of a quadrivalent inactivated influenza vaccine on influenza-associated complications and health care use in children aged 6 to 35 months: Analysis of data from a phase III trial in the Northern and Southern Hemispheres.
Sign Up to like & getrecommendations! Published in 2019 at "Vaccine"
DOI: 10.1016/j.vaccine.2019.01.059
Abstract: BACKGROUND A multi-season phase III trial conducted in the Northern and Southern Hemispheres demonstrated the efficacy of a quadrivalent split-virion inactivated influenza vaccine (IIV4) in children 6-35 months of age. METHODS Data collected during the phase… read more here.
Keywords: trial; children aged; iii trial; phase iii ... See more keywords
Randomized phase III trial of post-operative chemotherapy for patients with stage I/II/III small bowel adenocarcinoma (JCOG1502C, J-BALLAD).
Sign Up to like & getrecommendations! Published in 2018 at "Japanese journal of clinical oncology"
DOI: 10.1093/jjco/hyy188
Abstract: A randomized phase III trial was initiated in May 2017 to confirm the superiority of post-operative therapy with capecitabine and oxaliplatin over observation in terms of relapse-free survival in patients with curatively resected small bowel… read more here.
Keywords: small bowel; trial; iii trial; phase iii ... See more keywords
Savolitinib Heads for Phase III Trial in PRCC.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2017-105
Abstract: A phase II trial of savolitinib, a MET inhibitor, found that the drug induced partial responses in some patients with papillary renal cell carcinoma and was well tolerated, prompting drug makers Chi-Med and AstraZeneca to… read more here.
Keywords: trial; savolitinib heads; heads phase; iii trial ... See more keywords
A randomized phase III trial on the role of esophagectomy in complete responders to preoperative chemoradiotherapy (CRT) for esophageal squamous cell carcinoma (ESCC).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.4020
Abstract: 4020Background: To investigate the role of esophagectomy in pts who achieved clinical complete response (cCR) with CRT for locally advanced ESCC. Methods: Pts with resectable cT3-T4a anyN M0 or any... read more here.
Keywords: role esophagectomy; iii trial; randomized phase; phase iii ... See more keywords
Dacomitinib versus gefitinib for the first-line treatment of advanced EGFR mutation positive non-small cell lung cancer (ARCHER 1050): A randomized, open-label phase III trial.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.18_suppl.lba9007
Abstract: LBA9007Background: Dacomitinib is a 2nd generation EGFR TKI with encouraging clinical activity as 1st-line therapy in patients with EGFR-activating mutation positive advanced NSCLC (Janne, Lancet Oncol 2014). We performed the first randomized phase III trial,… read more here.
Keywords: egfr mutation; line; mutation positive; iii trial ... See more keywords
CTONG1104: Adjuvant gefitinib versus chemotherapy for resected N1-N2 NSCLC with EGFR mutation—Final overall survival analysis of the randomized phase III trial 1 analysis of the randomized phase III trial.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.9005
Abstract: 9005Background: ADJUVANT-CTONG1104, a randomized phase 3 trial showed adjuvant gefitinib treatment significantly improved disease-free survival (DFS) vs standard doublet chemotherapy in patients (p... read more here.
Keywords: phase; iii trial; randomized phase; phase iii ... See more keywords
A phase III trial of docetaxel versus docetaxel and radium-223 (Ra-223) in patients with metastatic castration-resistant prostate cancer (mCRPC): DORA.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.tps5594
Abstract: TPS348Background: Ra-223, a bone-targeted alpha therapy, is a well-tolerated treatment option that prolongs survival in patients (pts) with symptomatic mCRPC to bone. Docetaxel targets microtubule ... read more here.
Keywords: phase iii; mcrpc; docetaxel versus; docetaxel ... See more keywords
Fong’s Score in the Era of Modern Perioperative Chemotherapy for Metastatic Colorectal Cancer: A Post Hoc Analysis of the GERCOR-MIROX Phase III Trial
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Surgical Oncology"
DOI: 10.1245/s10434-019-07976-7
Abstract: Background Despite improvement in colorectal liver metastasis (CLM) treatment, survival after liver surgery remains highly variable. Several clinicopathologic prognostic factors have been reported, but their validity in the era of more effective perioperative chemotherapy remains… read more here.
Keywords: chemotherapy; analysis; perioperative chemotherapy; iii trial ... See more keywords