Discovery of benzo[cd]indol-2-one and benzylidene-thiazolidine-2,4-dione as new classes of NLRP3 inflammasome inhibitors via ER-β structure based virtual screening.
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DOI: 10.1016/j.bioorg.2019.103500
Abstract: The structure-guided virtual screening (VS) has proved to be successful strategy in identification of new scaffolds for biological targets. The overactivity of NLRP3 inflammasome has been implicated in variety of inflammatory diseases including Alzheimer's disease.… read more here.
Keywords: virtual screening; inflammasome inhibitors; inhibitors via; structure ... See more keywords