Electronic Expression of IK1 in Human Induced Pluripotent Stem Cell Derived Cardiac Myocytes (hiPSCD-CM) Alters Action Potential Response to Channel Block
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1289
Abstract: The hiPSCD-CM system provides a unique way to examine cardiac repolarization. However, the lack of, or low, expression endogenous IK1 results in spontaneous behavior that interferes with measurement of action potential (AP) parameters such as… read more here.
Keywords: control; action potential; electronic expression; ik1 ... See more keywords
Reciprocal interaction between IK1 and If in biological pacemakers: A simulation study
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DOI: 10.1371/journal.pcbi.1008177
Abstract: Pacemaking dysfunction (PD) may result in heart rhythm disorders, syncope or even death. Current treatment of PD using implanted electronic pacemakers has some limitations, such as finite battery life and the risk of repeated surgery.… read more here.
Keywords: pacemaker; interaction ik1; biological pacemakers; reciprocal interaction ... See more keywords
Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.794620
Abstract: The congenital short QT syndrome (SQTS) is a cardiac condition that leads to abbreviated ventricular repolarization and an increased susceptibility to arrhythmia and sudden death. The SQT3 form of the syndrome is due to mutations… read more here.
Keywords: syndrome; repolarization; d172n; mutation ... See more keywords