Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity
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DOI: 10.1038/s41375-019-0474-0
Abstract: Ikaros encodes a transcription factor that functions as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL). The mechanisms through which Ikaros regulates gene expression and cellular proliferation in T-ALL are unknown. Re-introduction of Ikaros… read more here.
Keywords: ikaros tumor; tumor suppressor; activity; super enhancers ... See more keywords