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Published in 2019 at "Cytokine"
DOI: 10.1016/j.cyto.2019.01.005
Abstract: HighlightsIKBKE is frequently overexpressed or activated in a variety of human cancers.We identified a specific IKBKE inhibitors, malachite green oxalate (MCCK1), which directly inhibited IKBKE kinase activity as well as its downstream targets such as…
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Keywords:
ikbke;
ikbke inhibitor;
cancer cells;
cancer ... See more keywords
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Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-15-1684
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies lacking effective therapeutic strategies. Here, we show that the noncanonical IκB-related kinase, IKBKE, is a critical oncogenic effector during KRAS-induced pancreatic transformation. Loss of IKBKE…
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Keywords:
kras induced;
ikbke required;
pancreatic tumorigenesis;
induced pancreatic ... See more keywords