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   Articles with "ikk" as a keyword



MiR-200b attenuates IL-6 production through IKKβ and ZEB1 in human gingival fibroblasts

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recommendations! Published in 2018 at "Inflammation Research"

DOI: 10.1007/s00011-018-1192-1

Abstract: ObjectiveMicroRNAs (miRNAs) play important roles in biological processes such as cell differentiation, development, infection, immune response, inflammation and tumorigenesis. We previously reported that the expression of miR-200b was significantly increased in inflamed gingiva compared with… read more here.

Keywords: gingival fibroblasts; mir 200b; ikk; ikk zeb1 ... See more keywords
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A constitutively-active IKK-complex at the axon initial segment

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2017.10.020

Abstract: BACKGROUND Previous studies provided evidence for an accumulation of IκB-kinase (IKK) α/β at the axon initial segment (AIS), a neuronal compartment defined by ankyrin-G expression. Here we explored whether the presence of the IKK-complex at… read more here.

Keywords: initial segment; axon initial; constitutively active; ikk ... See more keywords

Cross-talk between Bcl-2 and IKK in 4-hydroxynonenal-induced apoptosis

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.05.013

Abstract: Apoptosis of macrophage foam cells loaded with modified/oxidized lipids is implicated in destabilization of advanced atherosclerotic plaques in humans. Concentration of HNE, main aldehydic product of plasma LDL peroxidation, elevates in atherosclerotic lesions as well… read more here.

Keywords: apoptosis; induced apoptosis; ikk; bcl ... See more keywords

IKKβ targeting reduces KRAS-induced lung cancer angiogenesis in vitro and in vivo: A potential anti-angiogenic therapeutic target.

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recommendations! Published in 2019 at "Lung cancer"

DOI: 10.1016/j.lungcan.2019.02.027

Abstract: OBJECTIVES The ability of tumor cells to drive angiogenesis is an important cancer hallmark that positively correlates with metastatic potential and poor prognosis. Therefore, targeting angiogenesis is a rational therapeutic approach and dissecting proangiogenic pathways… read more here.

Keywords: kras induced; angiogenesis; ikk; lung cancer ... See more keywords

Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

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recommendations! Published in 2017 at "Journal of Medicinal Chemistry"

DOI: 10.1021/acs.jmedchem.7b00484

Abstract: IKKβ plays a central role in the canonical NF-kB pathway, which has been extensively characterized. The role of IKKα in the noncanonical NF-kB pathway, and indeed in the canonical pathway as a complex with IKKβ,… read more here.

Keywords: canonical pathway; inhibitory kappa; kappa kinase; pathway ... See more keywords
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Crosstalk of the IκB Kinase with Spliced X-Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial-Mesenchymal Transition.

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recommendations! Published in 2021 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.1c00093

Abstract: Epithelial-mesenchymal transition (EMT) plays a critical role in airway injury, repair, and structural remodeling. IκB kinase (IKK)-NFκB signaling regulates late EMT-associated gene expression. However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression,… read more here.

Keywords: protein; mesenchymal transition; emt; kinase ... See more keywords

Nuclear versus cytoplasmic IKKα signaling in keratinocytes leads to opposite skin phenotypes and inflammatory responses, and a different predisposition to cancer

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recommendations! Published in 2024 at "Oncogene"

DOI: 10.1038/s41388-024-03203-0

Abstract: IKKα is known as an essential protein for skin homeostasis. However, the lack of suitable models to investigate its functions in the skin has led to IKKα being mistakenly considered as a suppressor of non-melanoma… read more here.

Keywords: cancer; different predisposition; opposite skin; skin ... See more keywords
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Characterization of a small-molecule inhibitor targeting NEMO/IKKβ to suppress colorectal cancer growth

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recommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-022-00888-1

Abstract: NEMO/IKKβ complex is a central regulator of NF-κB signaling pathway, its dissociation has been considered to be an attractive therapeutic target. Herein, using a combined strategy of molecular pharmacological phenotyping, proteomics and bioinformatics analysis, Shikonin… read more here.

Keywords: small molecule; nemo ikk; inhibitor; ikk ... See more keywords
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CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation

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recommendations! Published in 2020 at "Cell Death and Differentiation"

DOI: 10.1038/s41418-020-00656-0

Abstract: CRSP8 plays an important role in recruiting mediators to genes through direct interaction with various DNA-bound transactivators. In this study, we uncovered the unique function of CRSP8 in suppressing thyroid cancer differentiation and promoting thyroid… read more here.

Keywords: thyroid cancer; differentiation; ikk; cancer ... See more keywords

Inhibition of IKKβ/NF-κB signaling pathway to improve Dasatinib efficacy in suppression of cisplatin-resistant head and neck squamous cell carcinoma.

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recommendations! Published in 2020 at "Cell death discovery"

DOI: 10.1038/s41420-020-0270-7

Abstract: Proto-oncogene tyrosine-protein kinase Src plays an important role in Head and Neck Squamous Cell Carcinoma (HNSCC). However, the FDA-approved SRC inhibitor Dasatinib shows very limited efficacy in HNSCC clinical trials, even though Dasatinib can completely… read more here.

Keywords: cisplatin resistant; dasatinib; hnscc; ikk ... See more keywords

African-ancestry-specific variant IKKβ p.Glu502Lys confers high lupus risk.

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recommendations! Published in 2025 at "Nature genetics"

DOI: 10.1038/s41588-025-02398-6

Abstract: Cutaneous lupus erythematosus (CLE) is an autoimmune disease of the skin, occurring with or without systemic lupus erythematosus (SLE). People with African ancestry have a higher risk than people with other ancestries of developing lupus1… read more here.

Keywords: lupus; african ancestry; people african; risk ... See more keywords