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   Articles with "ikk complex" as a keyword



RNF8 negatively regulates NF-kappaB signaling by targeting IkappaB kinase: implications for the regulation of inflammation signaling.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.05.033

Abstract: Persistent or excess activation of NF-κB leads to cancer, autoimmune and inflammatory diseases. Therefore, activated NF-κB needs to be terminated after induction, which highlights the physiological significance of NF-κB-negative regulators. However, the molecular mechanisms that… read more here.

Keywords: rnf8; kinase; activation; ikk complex ... See more keywords
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A constitutively-active IKK-complex at the axon initial segment

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recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2017.10.020

Abstract: BACKGROUND Previous studies provided evidence for an accumulation of IκB-kinase (IKK) α/β at the axon initial segment (AIS), a neuronal compartment defined by ankyrin-G expression. Here we explored whether the presence of the IKK-complex at… read more here.

Keywords: initial segment; axon initial; constitutively active; ikk ... See more keywords

The NEMO/ATM/IKKα complex: A key player in colorectal cancer progression and treatment.

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recommendations! Published in 2025 at "Science signaling"

DOI: 10.1126/scisignal.adv1265

Abstract: The kinase IKKα phosphorylates the kinase ATM, enhancing its ability to promote DNA repair. In this issue of Science Signaling, Alonso-Marañón et al. demonstrate that in colorectal cancer cells, the IKK regulatory subunit NEMO targets the… read more here.

Keywords: colorectal cancer; atm ikk; nemo atm; ikk ... See more keywords

Bioinformatic Analysis of IKK Complex Genes Expression in Selected Gastrointestinal Cancers

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms25189868

Abstract: Gastrointestinal cancers account for over a quarter of all cancer cases and are associated with poor prognosis and high mortality rates. The IKK complex (the canonical I kappa B kinase), comprising the CHUK, IKBKB, and… read more here.

Keywords: adenocarcinoma; selected gastrointestinal; expression; ikk ... See more keywords