Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.
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DOI: 10.1016/j.celrep.2017.09.082
Abstract: Regulatory T cells (Tregs) prevent autoimmunity but limit antitumor immunity. The canonical NF-κB signaling pathway both activates immunity and promotes thymic Treg development. Here, we report that mature Tregs continue to require NF-κB signaling through IκB-kinase β… read more here.
Keywords: prolonged ikk; inhibition; regulatory cells; ctl ... See more keywords