IKK-mediated CYLD phosphorylation and cellular redox activity
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DOI: 10.1186/s10020-022-00439-y
Abstract: Oxidative stress is important in the development of obesity-related nephropathy (ORN). A causal relationship between IKK and ORN via CYLD-mediated inhibition of NRF2 has been described. However, contradictory explanations about the functioning of the mechanisms… read more here.
Keywords: redox activity; phosphorylation cellular; cellular redox; ikk mediated ... See more keywords
MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKβ and inducing IKKβ-mediated FoxO1 nuclear export and Foxp3 downregulation
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DOI: 10.7150/thno.72148
Abstract: Rationale: GLK (MAP4K3) activates PKCθ-IKKβ axis in T-cell activation and induces IL-17A-mediated autoimmune diseases. Attenuation of Treg differentiation and function by GLK could also contribute to autoimmune diseases. Methods: We analyzed the roles of GLK… read more here.
Keywords: treg differentiation; glk; nuclear export; ikk mediated ... See more keywords