Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2017.00759
Abstract: The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, IKr, underlie SQTS variant 1 (SQT1), in which… read more here.
Keywords: short syndrome; ikr; block; sqt1 ... See more keywords
mTOR Modulation of IKr through hERG1b-Dependent Mechanisms in Lipotoxic Heart
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DOI: 10.3390/ijms23158061
Abstract: In the atria, the rapid delayed rectifier channel (IKr) is a critical contributor to repolarization. In lipotoxic atria, increased activity of the serine/threonine mammalian target of rapamycin (mTOR) may remodel IKr and predispose patients to… read more here.
Keywords: herg1b; mtor modulation; modulation ikr; ikr ... See more keywords