Single channel kinetic analysis of the cAMP effect on IKs mutants, S209F and S27D/S92D
Sign Up to like & getrecommendations! Published in 2018 at "Channels"
DOI: 10.1080/19336950.2018.1499369
Abstract: ABSTRACT The IKs current is important in the heart’s response to sympathetic stimulation. β-adrenergic stimulation increases the amount of IKs and creates a repolarization reserve that shortens the cardiac action potential duration. We have recently… read more here.
Keywords: camp; analysis; iks; s27d s92d ... See more keywords
Human leukocyte antigen F-associated transcript 10 regulates the IKs potassium channel by competing for Kv7.1 ubiquitination
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DOI: 10.1098/rstb.2022.0167
Abstract: The protein expression and function changes from the slow-delayed rectifying K+ current, IKs, are tightly associated with ventricular cardiac arrhythmias. Human leukocyte antigen F-associated transcript 10 (FAT10), a member of the ubiquitin-like-modifier family, exerts a… read more here.
Keywords: antigen associated; iks; fat10; kv7 ubiquitination ... See more keywords
A Possible Explanation for the Low Penetrance of Pathogenic KCNE1 Variants in Long QT Syndrome Type 5
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DOI: 10.3390/ph15121550
Abstract: Long QT syndrome (LQTS) is an inherited cardiac rhythm disorder associated with increased incidence of cardiac arrhythmias and sudden death. LQTS type 5 (LQT5) is caused by dominant mutant variants of KCNE1, a regulatory subunit… read more here.
Keywords: iks; long syndrome; kcne1; kcne1 variants ... See more keywords