Selective activation of adrenoceptors potentiates IKs current in pulmonary vein cardiomyocytes through the protein kinase A and C signaling pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2021.08.004
Abstract: Delayed rectifier K+ current (IKs) is a key contributor to repolarization of action potentials. This study investigated the mechanisms underlying the adrenoceptor-induced potentiation of IKs in pulmonary vein cardiomyocytes (PVC). PVC were isolated from guinea… read more here.
Keywords: iks current; pulmonary vein; activation; protein kinase ... See more keywords
Specific protein kinase C isoform exerts chronic inhibition on the slowly activating delayed-rectifier potassium current by affecting channel trafficking
Sign Up to like & getrecommendations! Published in 2021 at "Channels"
DOI: 10.1080/19336950.2021.1882112
Abstract: ABSTRACT The slowly activating delayed rectifier K+ current (IKs) plays a key role in the repolarization of ventricular action potential in the human heart and is formed by the pore-forming α-subunit encoded by KCNQ1 (Kv7.1)… read more here.
Keywords: slowly activating; delayed rectifier; chronic inhibition; iks current ... See more keywords