Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.10.003
Abstract: Multiple myeloma remains an incurable disease, and continued efforts are required to develop novel agents and novel drug combinations with more effective anti-myeloma activity. Here, we show that the pan-PIM kinase inhibitors SGI1776 and CX6258… read more here.
Keywords: pan pim; ikzf1; myeloma; pim kinase ... See more keywords
It's ALL in the Family: IKZF1 and Hereditary Leukemia.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.04.008
Abstract: IKZF1 plays an essential role in lymphopoiesis, and somatic IKZF1 variants in acute lymphoblastic leukemia (ALL) are associated with poor prognosis. In this issue of Cancer Cell, Churchman et al. add to the list of leukemia… read more here.
Keywords: hereditary leukemia; family ikzf1; ikzf1 hereditary; leukemia ... See more keywords
THU0070 The transcription factors ikaros and aiolos are expressed in the synovial membrane of early rheumatoid arthritis patients in association with synovial lymphoid aggregates
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.6442
Abstract: Background IKZF1 (Ikaros) and IKZF3 (Aiolos) are transcription factors acting as regulators of the immune system development. Specifically, they are essential for the maturation, differentiation and survival of B cells. Polymorphisms of IKZF1 and 3… read more here.
Keywords: ikaros aiolos; early rheumatoid; arthritis; transcription factors ... See more keywords
Targeting Oncoproteins with a Positive Selection Assay for Protein Degraders
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DOI: 10.1182/blood-2020-141558
Abstract: Cancer genome sequencing studies have identified frequent driver mutations that alter the function of transcription factors (TFs). However, most TFs, are classically "undruggable". The discovery that IMiDs [immunomodulatory drugs e.g.Lenalidomide (LEN) and Pomalidomide (POM)] exert… read more here.
Keywords: dck ikzf1; pom; dck; spautin ... See more keywords
Loss-of-function but not dominant-negative intragenic IKZF1 deletions are associated with an adverse prognosis in adult BCR-ABL-negative acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Haematologica"
DOI: 10.3324/haematol.2016.161273
Abstract: Genetic alterations of the transcription factor IKZF1 (“IKAROS”) are detected in around 15–30% of cases of BCR-ABL-negative B-cell precursor acute lymphoblastic leukemia. Different types of intragenic deletions have been observed, resulting in a functionally inactivated… read more here.
Keywords: dominant negative; lymphoblastic leukemia; loss function; acute lymphoblastic ... See more keywords