Hierarchical governance of cytokine production by 6‐sulfo LacNAc (slan) dendritic cells for the control of psoriasis pathogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13170
Abstract: The skin immune system comprises a heterogeneous network of local cellular immune mediators. Their complex interplay establishes an efficient firstline barrier defense against pathogens and other environmental assaults. It also assures immune homeostasis and tolerance… read more here.
Keywords: production; il1; psoriasis; th17 cell ... See more keywords
Inhibition of IL1β by Canakinumab May Be Effective against Diverse Molecular Subtypes of Lung Cancer: An Exploratory Analysis of the CANTOS Trial
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DOI: 10.1158/0008-5472.can-19-3176
Abstract: These findings suggest that targeting the IL1β inflammatory pathway might be critical in reducing tumor-promoting inflammation and lung cancer incidence. In the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS), inhibition of the IL1β inflammatory pathway by… read more here.
Keywords: canakinumab; lung cancer; cancer; cantos ... See more keywords
NFκB-Mediated Invasiveness in CD133+ Pancreatic TICs Is Regulated by Autocrine and Paracrine Activation of IL1 Signaling
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DOI: 10.1158/1541-7786.mcr-17-0221
Abstract: Tumor-initiating cells (TIC) have been implicated in pancreatic tumor initiation, progression, and metastasis. Among different markers that define this cell population within the tumor, the CD133+ cancer stem cell (CSC) population has reliably been described… read more here.
Keywords: cd133; il1; expression; cancer ... See more keywords
Subcapsular Sinus Macrophages Promote Melanoma Metastasis to the Sentinel Lymph Nodes via an IL1α–STAT3 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-22-0225
Abstract: The authors show that subcapsular sinus macrophages promote aggressiveness of metastatic melanoma cells by releasing IL1α, which upregulates STAT3 signaling in the tumor. Blocking IL1α could synergize with STAT3 inhibitors in treating metastatic melanoma. read more here.
Keywords: promote melanoma; subcapsular sinus; il1; macrophages promote ... See more keywords
Preclinical development of combination therapy targeting the dominant cytokine interleukin-1β for renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e14237
Abstract: e14237 Background: Targeting myeloid-derived suppressor cells (MDSCs), key mediators of intrinsic and adaptive immune resistance, remains a significant challenge in kidney cancer immunotherapy. One potential driver of MDSC mediated tumor immunosuppression is the cytokine interleukin-1… read more here.
Keywords: therapy; pd1; combination; pd1 il1 ... See more keywords
May the Nitrosative and Carbonyl Stress Promote Inflammation in Patients with Colorectal Cancer?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s374387
Abstract: Purpose Overproduction of reactive nitrogen species (RNS) causes the nitrosative stress, which plays a vital role in the development of metabolic, inflammatory, and cancerous diseases. However, the role of nitrosative and carbonyl stress in the… read more here.
Keywords: il1; stress; crc patients; promote inflammation ... See more keywords
Gut Region-Specific Interleukin 1β Induction in Different Myenteric Neuronal Subpopulations of Type 1 Diabetic Rats
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065804
Abstract: Interleukin 1β (IL1β) is a pro-inflammatory cytokine that may play a crucial role in enteric neuroinflammation in type 1 diabetes. Therefore, our goal is to evaluate the effects of chronic hyperglycemia and insulin treatment on… read more here.
Keywords: different myenteric; myenteric neurons; myenteric neuronal; neuronal subpopulations ... See more keywords