Interleukin-11 up-regulates endoplasmic reticulum stress induced target, PDIA4 in human first trimester placenta and in vivo in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Placenta"
DOI: 10.1016/j.placenta.2017.04.007
Abstract: Interleukin (IL)11 is a crucial factor for human trophoblast function and placentation. Elevated levels are associated with pregnancy complications including preeclampsia, intrauterine growth restriction (IUGR) and preterm birth. However, the regulation of IL11 in the… read more here.
Keywords: endoplasmic reticulum; il11; reticulum stress; placenta ... See more keywords
The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling
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DOI: 10.1038/s41467-021-24631-6
Abstract: Hypoxia plays a critical role in tumor progression including invasion and metastasis. To determine critical genes regulated by hypoxia that promote invasion and metastasis, we screen fifty hypoxia inducible genes for their effects on invasion.… read more here.
Keywords: maff; invasion; il11; stat3 ... See more keywords
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis
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DOI: 10.1038/s41598-021-93623-9
Abstract: Loss of function (LOF) in IL11RA infers IL11 signaling as important for fertility, fibrosis, inflammation and incompletely penetrant craniosynostosis. The impact of LOF in IL11 has not been characterized. We generated IL11 knockout (Il11−/−) mice… read more here.
Keywords: il11 mice; craniosynostosis; il11; inflammation ... See more keywords
Xenopus laevis il11ra.L is an experimentally proven interleukin-11 receptor component that is required for tadpole tail regeneration
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DOI: 10.1038/s41598-022-05954-w
Abstract: Xenopus laevis tadpoles possess high regenerative ability and can regenerate functional tails after amputation. An early event in regeneration is the induction of undifferentiated cells that form the regenerated tail. We previously reported that interleukin-11… read more here.
Keywords: tail regeneration; il11ra; il11; receptor ... See more keywords
OS06.7 PI-3Kγ inhibition suppresses glioblastoma tumorigenicity through disruption of an IL11-STAT3-MYC signaling axis between microglia and glioblastoma.
Sign Up to like & getrecommendations! Published in 2017 at "Neuro-oncology"
DOI: 10.1093/neuonc/nox036.041
Abstract: AbstractWhile mutations in isocitrate dehydrogenase (IDH) gene are associated with favorable prognosis in glioblastoma patients, the biologic basis for favorable survival in patients with wild-type IDH (wtIDH) glioblastoma remains poorly understood. We identified that an… read more here.
Keywords: glioblastoma tumorigenicity; glioblastoma; il11; stat3 myc ... See more keywords
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signaling underlies TGFβ-mediated activation of dermal fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab168
Abstract: OBJECTIVES Interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts from patients with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically linked with activation of human dermal fibroblasts (HDFs) from patients… read more here.
Keywords: il11; erk; systemic sclerosis; hdfs ... See more keywords
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aba8146
Abstract: Inhibition of IL11 signaling limits drug-induced liver damage and promotes hepatic regeneration in a mouse model. A matter of species specificity Acetaminophen (APAP) overdose can cause liver injury; effective therapies for treating APAP poisoning beyond… read more here.
Keywords: induced liver; il11; apap; liver injury ... See more keywords
Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137089
Abstract: N-acetyl-p-aminophenol (APAP)-induced liver damage is associated with upregulation of Interleukin-11 (IL11), which is thought to stimulate IL6ST (gp130)-mediated STAT3 activity in hepatocytes, as a compensatory response. However, recent studies have found IL11/IL11RA/gp130 signaling to be… read more here.
Keywords: il11; liver injury; apap induced; induced liver ... See more keywords
Oxygen–Glucose Deprivation Promoted Fibroblast Senescence and Collagen Expression via IL11
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012090
Abstract: Cell senescence is one of the most important forms of injury induced by cardiovascular and other ischemic diseases. Fibroblasts are important participants in tissue repair after ischemic injury and the main source of IL11 secretion.… read more here.
Keywords: expression; fibroblast senescence; senescence; senescence collagen ... See more keywords