First-in-Human Phase I Trial of a Tumor-Targeted Cytokine (NHS-IL12) in Subjects with Metastatic Solid Tumors
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DOI: 10.1158/1078-0432.ccr-18-1512
Abstract: Purpose: The NHS-IL12 immunocytokine is composed of two IL12 heterodimers fused to the NHS76 antibody. Preclinical studies have shown that this antibody targets IL12 to regions of tumor necrosis by binding histones on free DNA… read more here.
Keywords: phase; il12; nhs il12; solid tumors ... See more keywords