An MSN-PEG-IP drug delivery system and IL13Rα2 as targeted therapy for glioma.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale"
DOI: 10.1039/c6nr08786h
Abstract: A combination of gene therapy and chemotherapy has recently received interest as a targeted therapy for glioma. A mesoporous silica nanoparticle (MSN)-based vehicle coated with IL13Rα2-targeted peptide (IP) using polyethylene glycol (PEG), MSN-PEG-IP (MPI), was… read more here.
Keywords: il13r; glioma; targeted therapy; msn ... See more keywords
CTIM-21. PRELIMINARY PERFUSION IMAGING RESULTS FROM PHASE 1 STUDY OF IL13RΑ2-TARGETED CAR-T CELLS FOR LEPTOMENINGEAL BRAIN TUMORS
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0478
Abstract: Leptomeningeal disease (LD) from IL13Rα2-positive brain cancer is associated with poor prognosis, with current therapies offering limited efficacy and control. IL13Rα2-targeted CAR-T cells represent a promising therapeutic strategy, potentially overcoming the barriers of the central… read more here.
Keywords: brain; targeted car; il13r; il13r targeted ... See more keywords
Abstract 708: Characterization of MDNA132, an IL-13 decoy receptor selective superkine for targeted delivery of immunotherapies to the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-708
Abstract: Background: Interleukin-13 (IL-13) exhibits high affinity for the IL-13 decoy receptor (IL13Rα2) but retains binding to IL13α1, a component of the functional Type II IL4R complex (IL4Rα/IL13Rα1) that elicits a Th2 immune response. IL13Rα2 expression… read more here.
Keywords: il13r; anti pd1; mdna132; decoy receptor ... See more keywords
IL13Rα2 siRNA inhibited cell proliferation, induced cell apoptosis, and suppressed cell invasion in papillary thyroid carcinoma cells
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s153703
Abstract: Aim Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Infiltrative growth and metastasis are the two most intractable characteristics of PTC. Interleukin-13 receptor α2 (IL13Rα2) with high affinity for Th2-derived cytokine… read more here.
Keywords: il13r; apoptosis; cell proliferation; cell apoptosis ... See more keywords
A Novel Role of IL13Rα2 in the Pathogenesis of Proliferative Vitreoretinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.831436
Abstract: Proliferative vitreoretinopathy (PVR), an inflammatory and fibrotic blinding disease, is still a therapeutic challenge. Retinal pigment epithelial (RPE) cells dislodged in the vitreous play a central role in the PVR pathogenesis. To identify potential novel… read more here.
Keywords: novel role; il13r; pathogenesis; arpe cells ... See more keywords