3035 – THE IL1-IL1RAP AXIS PLAYS AN IMPORTANT ROLE IN THE INFLAMMATORY LEUKEMIC NICHE THAT FAVORS ACUTE MYELOID LEUKEMIA CELL PROLIFERATION OVER NORMAL HEMATOPOIESIS
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.09.055
Abstract: Upregulation of the plasma membrane receptor IL1RAP in Acute Myeloid Leukemia (AML) has been reported but its role in the context of the leukemic bone marrow niche is unclear. We studied the signaling events downstream… read more here.
Keywords: myeloid leukemia; acute myeloid; cell proliferation; il1rap ... See more keywords
First-in-human phase 1 dose-escalation study of CAN04, a first-in-class interleukin-1 receptor accessory protein (IL1RAP) antibody in patients with solid tumours.
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DOI: 10.1038/s41416-021-01657-7
Abstract: BACKGROUND Interleukin-1 (IL-1) signalling is involved in various protumoural processes including proliferation, immune evasion, metastasis and chemoresistance. CAN04 is a first-in-class monoclonal antibody that binds IL-1 receptor accessory protein (IL1RAP), required for IL-1 signalling. In… read more here.
Keywords: study; phase; antibody; dose ... See more keywords
Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome.
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DOI: 10.1093/intimm/dxz081
Abstract: Nephrotic syndrome (NS) is a renal disease characterized by severe proteinuria and hypoproteinemia. Although several single-gene mutations have been associated with steroid-resistant NS, causative genes for steroid-sensitive NS (SSNS) have not been clarified. While seeking… read more here.
Keywords: steroid sensitive; biallelic variants; mutations il1rap; variants mutations ... See more keywords
The Role of SNPs in IL1RL1 and IL1RAP Genes in Age-related Macular Degeneration Development and Treatment Efficacy
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DOI: 10.21873/invivo.12059
Abstract: Background: Age-related macular degeneration (AMD) affects the central part of the retina and causes blindness. In developed countries, AMD occurs in people over 50 years old. Important factors for AMD pathogenesis are an immune response,… read more here.
Keywords: amd; age related; related macular; age ... See more keywords