Central role of B cells in interleukin-23 dependent neuroinflammation in the GF-IL23 model
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DOI: 10.1097/wnr.0000000000001818
Abstract: Interleukin (IL)-23 is one of the critical cytokines in autoimmune neuroinflammation. To further clarify the local function of IL-23 on the course of neuroinflammation, we recently established a transgenic mouse model with astrocyte-specific expression of… read more here.
Keywords: cell; neuroinflammation; model; il23 mice ... See more keywords
Abstract PR13: Pivotal role of interleukin 23 in osteosarcoma development and its link with glutamate metabotropic 4: Identification of novel therapeutic targets for osteosarcoma
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DOI: 10.1158/1557-3265.sarcomas17-pr13
Abstract: Objective: The 5-year survival of patients with metastatic or recurrent osteosarcoma is less than 25%. There is an urgent need to identify new treatment options for this cancer. Osteosarcomas represent a promising indication for strategies… read more here.
Keywords: il23; osteosarcoma; cancer; glutamate ... See more keywords
Abstract 2141: An IL12/IL23 Positive Feedback Loop Modulates Smooth Muscle Differentiation Via Setd4 During Macrophage-mediated Inflammation
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DOI: 10.1161/atvb.44.suppl_1.2141
Abstract: Diabetic patients have increased risk of vascular disease (e.g., atherosclerosis), which is driven by macrophage-mediated inflammation. In diseases such as atherosclerosis, smooth muscle cells (SMC) undergo phenotypic modulation from a mature, contractile to a synthetic… read more here.
Keywords: il23; smooth muscle; expression; smc ... See more keywords