Generation of novel Il2rg-knockout mice with clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9
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DOI: 10.1538/expanim.19-0120
Abstract: X-linked severe combined immunodeficiency (X-SCID) is an inherited genetic disorder. A majority of X-SCID subjects carries point mutations in the Interleukin-2 receptor gamma chain (IL2RG) gene. In contrast, Il2rg-knockout mice recapitulating X-SCID phenotype lack a… read more here.
Keywords: il2rg; crispr cas9; clustered regularly; knockout mice ... See more keywords