Obesity‐mediated upregulation of the YAP/IL33 signaling axis promotes aggressiveness and induces an immunosuppressive tumor microenvironment in breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30985
Abstract: Obesity is a well‐known risk factor for breast cancer formation and is associated with elevated mortality and a poor prognosis. An obesity‐mediated inflammatory microenvironment is conducive to the malignant progression of tumors. However, the detailed… read more here.
Keywords: obesity; breast cancer; il33; yap ... See more keywords
Interleukin33 deficiency causes tau abnormality and neurodegeneration with Alzheimer-like symptoms in aged mice
Sign Up to like & getrecommendations! Published in 2017 at "Translational Psychiatry"
DOI: 10.1038/tp.2017.142
Abstract: Late-onset Alzheimer’s disease (AD) remains a medical mystery. Recent studies have linked it to impaired repair of aged neurons. Potential involvement of interleukin33 (IL33) in AD has been reported. Here we show that IL33, which… read more here.
Keywords: il33; tau abnormality; neurodegeneration; aging surge ... See more keywords
Superkine IL2 and IL33 armored CAR T cells reshape the tumor microenvironment and reduce growth of multiple solid tumors.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0536
Abstract: Chimeric-antigen receptor (CAR) T-cell therapy has shown remarkable efficacy against hematologic tumors. Yet, CAR T-cell therapy has had little success against solid tumors due to obstacles presented by the tumor microenvironment (TME) of these cancers.… read more here.
Keywords: tumor; il33; tumor microenvironment; car ... See more keywords
The Risk of Genetic Polymorphisms in the Immune Genes on the Developed of Respiratory Allergic Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2022.00296
Abstract: Allergic diseases are intricate and improvement includes both natural and hereditary components. besides classic Tcell-originated T helper form-2 cytokine comparable to IL4; IL5; IL13. Tissues created cytokine akin to thymic-stromal-lymphopoietin. IL25 as well as IL33… read more here.
Keywords: polymorphisms immune; genetic polymorphisms; risk genetic; il33 ... See more keywords