Interleukin-4-carrying small extracellular vesicles with a high potential as anti-inflammatory therapeutics based on modulation of macrophage function.
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DOI: 10.1016/j.biomaterials.2021.121160
Abstract: Interleukin-4 (IL4), a Th2-type cytokine that can drive M2 macrophage polarization, is expected to be used as an anti-inflammatory therapy agent as M2 polarization of macrophages can ameliorate chronic inflammation. However, several problems, such as… read more here.
Keywords: anti inflammatory; extracellular vesicles; inflammatory therapeutics; il4 sevs ... See more keywords
The Role of Interleukin-4 and Interleukin-10 in Osteoarthritic Joint Disease: A Systematic Narrative Review
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DOI: 10.1177/19476035221098167
Abstract: Objective A fusion protein of interleukin-4 and interleukin-10 (IL4-10 FP) was developed as a disease-modifying osteoarthritis drug (DMOAD), and chondroprotection, anti-inflammation, and analgesia have been suggested. To better understand the mechanisms behind its potential as… read more here.
Keywords: narrative review; interleukin interleukin; review; disease ... See more keywords
Fabrication of Interleukin-4 Encapsulated Bioactive Microdroplets for Regulating Inflammation and Promoting Osteogenesis
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DOI: 10.2147/ijn.s397359
Abstract: Background Despite the inherent regenerative ability of bone, large bone defect regeneration remains a major clinical challenge for orthopedic surgery. Therapeutic strategies medicated by M2 phenotypic macrophages or M2 macrophage inducer have been widely used… read more here.
Keywords: bioactive microdroplets; mds il4; bioactive mds; encapsulated bioactive ... See more keywords
Effect on Osteogenic Differentiation of Genetically Modified IL4 or PDGF-BB Over-Expressing and IL4-PDGF-BB Co-Over-Expressing Bone Marrow-Derived Mesenchymal Stromal Cells In Vitro
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DOI: 10.3390/bioengineering8110165
Abstract: The use of genetically modified (GM) mesenchymal stromal cells (MSCs) and preconditioned MSCs (pMSCs) may provide further opportunities to improve the outcome of core decompression (CD) for the treatment of early-stage osteonecrosis of the femoral… read more here.
Keywords: il4 pdgf; pdgf expressing; pdgf mscs; il4 ... See more keywords
Controlling Macrophage Polarization to Modulate Inflammatory Cues Using Immune-Switch Nanoparticles
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DOI: 10.3390/ijms232315125
Abstract: The persistence of inflammatory mediators in tissue niches significantly impacts regenerative outcomes and contributes to chronic diseases. Interleukin-4 (IL4) boosts pro-healing phenotypes in macrophages (Mφ) and triggers the activation of signal transducer and activator of… read more here.
Keywords: spion; il4; inflammatory; polarization ... See more keywords