IL4/IL4R signaling promotes the osteolysis in metastatic bone of CRC through regulating the proliferation of osteoclast precursors
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DOI: 10.1186/s10020-021-00411-2
Abstract: Background Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is regulated in metastatic microenvironment caused by… read more here.
Keywords: bone; proliferation; il4 il4r; osteoclast precursors ... See more keywords