IL6/STAT3 axis mediates resistance to BRAF inhibitors in thyroid carcinoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.06.038
Abstract: Thyroid carcinomas (TCs) bearing BRAF mutations represent approximately 26-53% of human thyroid malignancies and, differently from melanomas, are poorly sensitive to BRAF inhibitors (BRAFi), and develop acquired resistance through activation of alternative signaling pathways. A… read more here.
Keywords: plx4032; braf; stat3 axis; il6 stat3 ... See more keywords
Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09405-5
Abstract: Caveolin-3 is the major structural protein of caveolae in muscle. Mutations in the CAV3 gene cause different types of myopathies with altered membrane integrity and repair, expression of muscle proteins, and regulation of signaling pathways.… read more here.
Keywords: il6; muscle; muscle cells; il6 stat3 ... See more keywords
An aquatic virus exploits the IL6-STAT3-HSP90 signaling axis to promote viral entry
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011320
Abstract: Viral seasonality in the aquaculture industry is an important scientific issue for decades. While the molecular mechanisms underpinning the temperature-dependent pathogenesis of aquatic viral diseases remain largely unknown. Here we report that temperature-dependent activation of… read more here.
Keywords: stat3 hsp90; il6 stat3; entry; viral entry ... See more keywords