Treatment of post‐transfusion hyperhaemolysis syndrome in Sickle Cell Disease with the anti‐IL6R humanised monoclonal antibody Tocilizumab
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.16103
Abstract: Post-transfusion hyperhaemolysis syndrome (PTHS) is a rare post-transfusion reaction seen primarily in patients with sickle cell disease (SCD). It is characterised by brisk haemolysis of both transfused and recipient red cells, also known as ‘By-stander’… read more here.
Keywords: il6r; treatment; transfusion; post ... See more keywords
Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Medicine"
DOI: 10.1371/journal.pmed.1004174
Abstract: Background Sepsis is characterised by dysregulated, life-threatening immune responses, which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in IL6R known to down-regulate IL-6 signalling are associated with improved… read more here.
Keywords: sepsis; effect; il6r blockade; critical care ... See more keywords
Investigation of genetic variations of IL6 and IL6R as potential prognostic and pharmacogenetics biomarkers: implications for COVID19 and neuroinflammatory disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Life"
DOI: 10.21203/rs.3.rs-77342/v1
Abstract: In the present study, we investigated the distribution of genetic variations in IL6 and IL6R genes, which may be employed as prognostic and pharmacogenetic biomarkers for COVID-19 and neurodegenerative diseases. The study was performed on… read more here.
Keywords: il6r; variations il6; investigation genetic; neuroinflammatory disorders ... See more keywords
IL6R gene polymorphisms and their relation to chronic obstructive pulmonary disease susceptibility in the Chinese population.
Sign Up to like & getrecommendations! Published in 2023 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2022-0342
Abstract: Background: This work was designed to explore the correlation between IL6R polymorphisms and chronic obstructive pulmonary disease (COPD) susceptibility. Methods: Agena MassARRAY was used to genotype five SNPs of IL6R in 498 patients with COPD and 498… read more here.
Keywords: obstructive pulmonary; chronic obstructive; susceptibility; pulmonary disease ... See more keywords