INPP5K controls the dynamic structure and signaling of wild type and mutated, leukemia-associated IL7 receptors.
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DOI: 10.1182/blood.2022017819
Abstract: Signaling downstream of the IL7 receptor plays important physiological and pathological roles, including differentiation of lymphoid cells and proliferation of acute lymphoblastic leukemia cells. Gain of function mutations in the IL7Rα chain, the specific component… read more here.
Keywords: structure; il7; dynamic structure; il7r chain ... See more keywords