Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils
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DOI: 10.1002/advs.202206958
Abstract: Development of abdominal aortic aneurysms (AAA) enhances lesion group‐2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rorafl/flIl7rCre/+ mice or induced ILC2 depletion in Icosfl‐DTR‐fl/+Cd4Cre/+ mice expedites AAA growth, increases lesion inflammation,… read more here.
Keywords: il5; ilc2; via il5; abdominal aortic ... See more keywords
Reduced numbers of circulating group 2 innate lymphoid cells in patients with common variable immunodeficiency
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DOI: 10.1002/eji.201746961
Abstract: Recent studies identified an emerging role of group 2 and 3 innate lymphoid cells (ILCs) as key players in the generation of T‐dependent and T‐independent antibody production. In this retrospective case‐control study, CD117+ ILCs (including… read more here.
Keywords: ilc2; reduction; patients common; group innate ... See more keywords
TSLP links intestinal nutrient sensing with amplification of the ILC2–tuft cell circuit
Sign Up to like & getrecommendations! Published in 2025 at "Nature Immunology"
DOI: 10.1038/s41590-025-02328-y
Abstract: Group 2 innate lymphocytes (ILC2s) are prevalent in small intestine but their role during homeostasis is unclear. Here we show that thymic stromal lymphopoietin (TSLP)—a cytokine implicated in ILC2 activation—is expressed constitutively in subepithelial fibroblasts, including… read more here.
Keywords: circuit; ilc2 activation; ilc2; tuft cell ... See more keywords
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells
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DOI: 10.1093/cvr/cvac144
Abstract: Abstract Aims Group 2 innate lymphoid cells (ILC2s) regulate adaptive and innate immunities. In mouse heart, production of myocardial infarction (MI) increased ILC2 accumulation, suggesting a role for ILC2 in cardiac dysfunction post-MI. Methods and… read more here.
Keywords: il5; ilc2; group innate; mice ... See more keywords
Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma.
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DOI: 10.1164/rccm.202311-2164oc
Abstract: RATIONALE In asthma, sputum group 2 innate lymphoid cells (ILC2) are activated within 7h after allergen challenge. Neuroimmune interactions mediate rapid host responses at mucosal interfaces. In murine models of asthma, lung ILC2 co-localize to… read more here.
Keywords: group innate; lymphoid cells; nmur1 ilc2; group ... See more keywords
Prostaglandin D2 metabolites activate asthmatic patient-derived type 2 innate lymphoid cells and eosinophils via the DP2 receptor
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DOI: 10.1186/s12931-021-01852-3
Abstract: Background Prostaglandin D 2 (PGD 2 ) signaling via prostaglandin D 2 receptor 2 (DP 2 ) contributes to atopic and non-atopic asthma. Inhibiting DP 2 has shown therapeutic benefit in certain subsets of asthma… read more here.
Keywords: ilc2; prostaglandin; cytokine secretion; pgd ... See more keywords
Human intrahepatic ILC2 are IL-13positive amphiregulinpositive and their frequency correlates with model of end stage liver disease score
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DOI: 10.1371/journal.pone.0188649
Abstract: Introduction Innate lymphoid cells (ILC) have been implicated in the initiation of inflammation and fibrosis in mice. However, ILC have not been characterized in inflamed human liver tissue. Methods Human intrahepatic lymphocytes were isolated by… read more here.
Keywords: ilc2; liver disease; human intrahepatic; intrahepatic ilc2 ... See more keywords
The Roles of Kidney-Resident ILC2 in Renal Inflammation and Fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.688647
Abstract: Innate lymphoid cells (ILCs) are a recently discovered lymphocyte population with high cytokine productive capacity. Type-2 ILCs (ILC2s) are the most studied, and they exert a rapid type-2 immune response to eliminate helminth infections. Massive… read more here.
Keywords: ilc2; various kidney; fibrosis; inflammation ... See more keywords