Interleukin‐33 increases type 2 innate lymphoid cell count and their activation in eosinophilic asthma
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12265
Abstract: Abstract Background Interleukin‐33 (IL‐33) exacerbates asthma probably through type 2 innate lymphoid cells (ILC2s). Nevertheless, the association between eosinophilic asthma (EA) and ILC2s remains obscure, and the mechanisms by which IL‐33 affects ILC2s are yet… read more here.
Keywords: interleukin; eosinophilic asthma; innate lymphoid; ilc2s ... See more keywords
IL‐4/IL‐13‐producing ILC2s are required for timely control of intestinal helminth infection in mice
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249892
Abstract: Infection of mice with Nippostrongylus brasiliensis (Nb) serves as a model for human hookworm infection affecting about 600 million people world‐wide. Expulsion of Nb from the intestine requires IL‐13‐mediated mucus secretion from goblet cells and… read more here.
Keywords: producing ilc2s; infection; infection mice; ilc2s required ... See more keywords
Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.103
Abstract: Group 2 innate lymphoid cells (ILC2s) are abundant in non-lymphoid tissues and increase following infectious and inflammatory insults. In solid tumors, however, ILC2s constitute a relatively small proportion of immune cells. Here, we show, using… read more here.
Keywords: lactic acid; tumor derived; ilc2s; derived lactic ... See more keywords
ILC2s - resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move?
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.11.001
Abstract: A cardinal feature of the T-cell adaptive immune system is the antigen-dependent activation of naïve T cells in secondary lymphoid sites, followed by the migration of the resultant effector cells through the efferent lymph to… read more here.
Keywords: migratory; iilc2 cells; infection; tissue ... See more keywords
ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-2015-4
Abstract: Group 2 innate lymphoid cells (ILC2s) regulate inflammation and immunity in mammalian tissues 1 , 2 . Although ILC2s are found in cancers of these tissues 3 , their roles in cancer immunity and immunotherapy… read more here.
Keywords: tissue specific; immunity; ilc2s; cancer immunity ... See more keywords
Exogenous IL-33 promotes tumor immunity via macroscopic regulation of ILC2s
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-77751-6
Abstract: Interleukin-33 (IL-33) is a pleiotropic molecule that plays various roles in the body. However, how exogenous IL-33 changes the tumor immune microenvironment remains unclear. Our study revealed that exogenous IL-33 exerts anti-tumor effects and effectively… read more here.
Keywords: promotes tumor; tumor immune; revealed exogenous; exogenous promotes ... See more keywords
IRF3 Promotes Asthma Pathogenesis by Regulating Type 2 Innate Lymphoid Cells
Sign Up to like & getrecommendations! Published in 2024 at "Immunological Investigations"
DOI: 10.1080/08820139.2024.2418935
Abstract: ABSTRACT Background Allergic asthma is characterized by airway hyperresponsiveness triggered by inhaled allergens. Type 2 innate lymphoid cells (ILC2s) have been demonstrated to play a crucial role in promoting airway inflammation through the secretion of… read more here.
Keywords: irf3; lymphoid cells; type innate; innate lymphoid ... See more keywords
IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s.
Sign Up to like & getrecommendations! Published in 2019 at "International immunology"
DOI: 10.1093/intimm/dxz077
Abstract: Group 2 innate lymphoid cells (ILC2s) play critical roles in type 2 immunity and are crucial for pathogenesis of various types of inflammatory disease. IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a ubiquitously expressed scaffold… read more here.
Keywords: lung ilc2s; containing gtpase; gtpase activating; ilc2s ... See more keywords
Phenotype, function and clinical significance of innate lymphoid cells in immunoglobulin G4-related disease.
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology"
DOI: 10.1093/rheumatology/keab610
Abstract: OBJECTIVE Innate immune system participates in immunoglobulin G4 related disease (IgG4-RD). While the role of innate lymphoid cells (ILCs) in IgG4-RD remains to be elucidated, we aimed to evaluate the phenotype, function and clinical significance… read more here.
Keywords: phenotype; innate; igg4; ilc2s ... See more keywords
Innate lymphoid cells coming of age
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15588
Abstract: Literature Watch 2669 R E P R IN TE D F R O M IM M U N IT Y, 5 0: 6, 2 01 9, 1 42 5– 38 , W IT H P… read more here.
Keywords: adult; expansion; tissue; ilc2s ... See more keywords
Severe asthma ILC2s demonstrate enhanced proliferation that is modified by biologics.
Sign Up to like & getrecommendations! Published in 2023 at "Respirology"
DOI: 10.1111/resp.14506
Abstract: BACKGROUND AND OBJECTIVE Type 2 (T2) innate lymphoid cells (ILC2s) contribute to airway inflammation and disease in asthma. We hypothesize that ILC2s isolated from people with severe allergic and eosinophilic asthma would exhibit an enhanced… read more here.
Keywords: mepolizumab omalizumab; proliferation; asthma; treatment ... See more keywords