Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.09.070
Abstract: A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood. Here, we employed an unbiased cross-tissue… read more here.
Keywords: ilc3s; residing ilc3s; cross tissue; organ residing ... See more keywords
IL-1β promotes IL-17A production of ILC3s to aggravate neutrophilic airway inflammation in mice.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13644
Abstract: IL-17A-producing group 3 innate lymphoid cells (ILC3s) have been found to participate in the development of various phenotypes of asthma, however, little is known about how ILC3s mediate neutrophilic airway inflammation. Elevated IL-1β has been… read more here.
Keywords: ilc3s; neutrophilic airway; airway inflammation; lung ... See more keywords
Innate lymphoid cells type 3 in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1033252
Abstract: Cancer is a multifactorial chronic illness caused by a combination of genetic and environmental factors. A tumor is more than just a collection of cancer cells, it also contains infiltrating and resident host cells that… read more here.
Keywords: ilc3s; cells type; innate lymphoid; type cancer ... See more keywords
The Transcription Factor ThPOK Regulates ILC3 Lineage Homeostasis and Function During Intestinal Infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.939033
Abstract: Innate lymphoid cells (ILCs) have been identified as a heterogeneous population of lymphocytes that mirrors the cytokine and transcriptional profile of adaptive T cells. The dynamic balance between key transcription factors determines the heterogeneity, plasticity,… read more here.
Keywords: ilc3s; infection; transcription factor; factor thpok ... See more keywords
MSI2 deficiency in ILC3s attenuates DSS-induced colitis by affecting the intestinal microbiota
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.963379
Abstract: Background The etiology and pathogenesis of inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), are generally believed to be related to immune dysfunction and intestinal microbiota disorder. However, the exact mechanism… read more here.
Keywords: intestinal microbiota; microbiota; ilc3s; dss induced ... See more keywords