Developmental options and functional plasticity of innate lymphoid cells.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2017.03.010
Abstract: Innate lymphoid cells (ILCs) are lineage- and antigen receptor-negative lymphocytes including natural killer (NK) cells and at least three distinguishable cell subsets (ILC1, ILC2, ILC3) that rapidly produce cytokines (IFN-γ, IL-5, IL-13, IL-17A, IL-22) upon… read more here.
Keywords: innate; ilcs; functional plasticity; innate lymphoid ... See more keywords
Unraveling the Heterogeneity and Specialization of ILCs.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.09.017
Abstract: In this issue of Immunity, Zeis et al. report the generation of a single-cell atlas of lung innate lymphoid cells (ILCs). Their findings provide insight into the how ILCs are locally maintained, revealing in situ differentiation… read more here.
Keywords: heterogeneity specialization; specialization ilcs; unraveling heterogeneity; ilcs ... See more keywords
Adoptive Transfer of Group 3-Like Innate Lymphoid Cells Restores Mouse Colon Resistance to Colonization of a Gamma Interferon-Susceptible Chlamydia muridarum Mutant
Sign Up to like & getrecommendations! Published in 2020 at "Infection and Immunity"
DOI: 10.1128/iai.00533-20
Abstract: The obligate intracellular bacterium Chlamydia muridarum can colonize the mouse colon for a long period, but a gamma interferon (IFN-γ)-susceptible mutant clone fails to do so. Nevertheless, the mutant’s colonization is rescued in mice deficient… read more here.
Keywords: chlamydia muridarum; ilcs; mice; colonization ... See more keywords
‘ILC-poiesis’: generating tissue ILCs from naïve precursors
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21046
Abstract: Innate lymphoid cells (ILC) are a newly described family of hematopoietic cells that lack antigen-specific receptors but can be activated to promptly produce large amounts of cytokines (including interleukin (IL)-5, -13, -17A, -22, TNF-α and… read more here.
Keywords: human ilcp; ilc poiesis; ilcs; tissue ... See more keywords
The Role of Innate Lymphoid Cells in Cancer Development and Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.803563
Abstract: Innate Lymphoid Cells (ILCs) are an elusive type of innate immune cell that was only discovered recently. Their tissue residency and dependency makes them a niche group of cells that bridge the adaptive and innate… read more here.
Keywords: microenvironment; role; innate lymphoid; ilcs ... See more keywords
Regulation of Innate Lymphoid Cells by Aryl Hydrocarbon Receptor
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01909
Abstract: With striking similarity to their adaptive T helper cell counterparts, innate lymphoid cells (ILCs) represent an emerging family of cell types that express signature transcription factors, including T-bet+ Eomes+ natural killer cells, T-bet+ Eomes− group… read more here.
Keywords: hydrocarbon receptor; aryl hydrocarbon; ilcs; innate lymphoid ... See more keywords
Characterization of Rat ILCs Reveals ILC2 as the Dominant Intestinal Subset
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.00255
Abstract: Innate lymphoid cells (ILCs) are tissue-resident lymphocytes that lack antigen-specific receptors and exhibit innate effector functions such as cytokine production that play an important role in immediate responses to pathogens especially at mucosal sites. Mouse… read more here.
Keywords: characterization rat; ilc subsets; ilcs; subset ... See more keywords
Innate lymphoid cells: More than just immune cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1033904
Abstract: Since their discovery, innate lymphoid cells (ILCs) have been described as the innate counterpart of the T cells. Indeed, ILCs and T cells share many features including their common progenitors, transcriptional regulation, and effector cytokine… read more here.
Keywords: innate lymphoid; ilcs; cells immune; tissue ... See more keywords
Altered Frequencies and Functions of Innate Lymphoid Cells in Melanoma Patients Are Modulated by Immune Checkpoints Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.811131
Abstract: Monoclonal antibodies targeting immune checkpoints improved clinical outcome of patients with malignant melanoma. However, the mechanisms are not fully elucidated. Since immune check-point receptors are also expressed by helper innate lymphoid cells (ILCs), we investigated… read more here.
Keywords: cd117 ilcs; melanoma patients; innate lymphoid; ilcs ... See more keywords
A single-cell map of vascular and tissue lymphocytes identifies proliferative TCF-1+ human innate lymphoid cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.902881
Abstract: Innate lymphoid cells (ILCs) play important roles in tissue homeostasis and host defense, but the proliferative properties and migratory behavior of especially human ILCs remain poorly understood. Here we mapped at single-cell resolution the spatial… read more here.
Keywords: cell; innate lymphoid; single cell; ilcs ... See more keywords
Specific Patterns of Blood ILCs in Metastatic Melanoma Patients and Their Modulations in Response to Immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13061446
Abstract: Simple Summary Anti-CTLA-4 and anti-PD-1 immune checkpoints inhibitors (ICI) have revolutionized the treatment of metastatic melanoma patients, leading to durable responses. However, some patients still not respond to this clinically used immunotherapies and there is… read more here.
Keywords: melanoma; response; treatment; ilcs ... See more keywords