P380 Comparison of mucosal healing through segments of ileocolonic Crohn’s disease treated with biologics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab076.504
Abstract: Although major advances in Inflammatory bowel disease’s treatment have been observed, the response to the pharmacologic therapies is still unpredictable and highly variable. Mucosal healing (MH) is an important endpoint in Crohn’s disease patients undergoing… read more here.
Keywords: response; ileal colonic; disease; mucosal healing ... See more keywords
OP40 Efficacy of risankizumab induction and maintenance therapy by baseline Crohn’s Disease location: Post hoc analysis of the phase 3 ADVANCE, MOTIVATE, and FORTIFY studies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab232.039
Abstract: In Crohn’s disease (CD), disease location affects treatment outcomes.1 This post hoc analysis assessed the efficacy of risankizumab (RZB), an interleukin 23 p19 inhibitor, by disease location. In ADVANCE (NCT03105128) and MOTIVATE (NCT03104413), patients with… read more here.
Keywords: therapy; endoscopic; remission; maintenance ... See more keywords
Furosemide suppresses ileal and colonic contractility via interactions with GABA‐A receptor in mice
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DOI: 10.1111/1440-1681.12824
Abstract: The loop diuretic furosemide has an action to inhibit Na+–K+–2Cl− co‐transporter at the thick ascending limb of Henle's loop resulting in diuresis. Furosemide also has the non‐diuretic effects by binding to GABA‐A receptor which may… read more here.
Keywords: furosemide; gaba receptor; contraction; receptor ... See more keywords
Special AT-rich sequence-binding protein 2 (SATB2) represses proximal small intestine identity in human pluripotent stem cell derived ileal and colonic organoids
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733706
Abstract: Background: Intestinal regional specification describes a process through which unique morphology and function are imparted to defined areas of the developing gastrointestinal (GI) tract. Human intestinal organoids can be generated from human pluripotent stem cells… read more here.
Keywords: cell; ileal colonic; colonic organoids; identity ... See more keywords
Marked Response of Rat Ileal and Colonic Microbiota After the Establishment of Alzheimer’s Disease Model With Bilateral Intraventricular Injection of Aβ (1-42)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.819523
Abstract: Alzheimer’s disease (AD) is a common neurodegenerative disease. More evidence has shown that gut microbiota is closely associated with AD. Also, studies have shown that the distribution of gut microbiota vary in different sections of… read more here.
Keywords: colonic microbiota; injection; model; disease ... See more keywords