Illuminating G-Protein-Coupling Selectivity of GPCRs
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DOI: 10.1016/j.cell.2019.04.044
Abstract: Heterotrimetic G proteins consist of four subfamilies (Gs, Gi/o, Gq/11, and G12/13) that mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding Gα C termini. G-protein-coupling profiles govern GPCR-induced cellular responses, yet receptor sequence… read more here.
Keywords: illuminating protein; protein coupling; coupling selectivity; gpcrs ... See more keywords