Boosting ionizable lipid nanoparticle-mediated in vivo mRNA delivery through optimization of lipid amine-head groups.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials science"
DOI: 10.1039/d1bm00866h
Abstract: In vitro transcribed messenger RNA (IVT-mRNA) holds great promise for the development of novel therapeutics, such as immunotherapy and vaccination. However, the main obstacle towards clinical translation is the lack of effective delivery systems. Herein,… read more here.
Keywords: head; ilnp; delivery; amine head ... See more keywords
Oral delivery of insulin-loaded nanoparticles in diabetic rabbits and in sheep
Sign Up to like & getrecommendations! Published in 2018 at "Czech Journal of Animal Science"
DOI: 10.17221/7495-cjas
Abstract: The objective of this study was to produce Eudragit ® RS 100 microparticles (ERS) containing insulin (ILNP), and to evaluate the potential of these nanoparticles as a drug carrier for oral administration in alloxan-induced diabetic… read more here.
Keywords: insulin; diabetic rabbits; rabbits sheep; oral delivery ... See more keywords