Using mirror-image peptides to enhance robustness and reproducibility in studying the amyloid β-protein.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.05.010
Abstract: Alzheimer's disease, the most common form of dementia, is a devastating disease that affects over 44 million people worldwide. One etiological agent of Alzheimer's, the amyloid β-protein (Aβ), is an aggregation-prone, intrinsically disordered peptide that… read more here.
Keywords: mirror image; using mirror; image peptides; amyloid protein ... See more keywords
Fabrication of cytotoxic mirror image nanopores
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64025-6
Abstract: Synthetic nanopores composed of mirror-image peptides have been reported, but not fully functional mirror-image pores. Here, we construct a monodisperse mirror-image nanopore, DpPorA and characterise its functional properties. Importantly, we alter the charge pattern and… read more here.
Keywords: mirror image; image; image peptides; cytotoxic mirror ... See more keywords