The Exception That Proves the Rule: How Sodium Chelation Can Alter the Charge‐Cell Binding Correlation of Fluorescein‐Based Multimodal Imaging Agents
Sign Up to like & getrecommendations! Published in 2022 at "Chemmedchem"
DOI: 10.1002/cmdc.202100739
Abstract: In the present study we describe and explain an aberrant behavior in terms of receptor binding profile of a fluorescein‐based multimodal imaging agent for gastrin releasing peptide receptor (GRPR) visualization by elucidating a chelating mechanism… read more here.
Keywords: fluorescein based; multimodal imaging; charge; based multimodal ... See more keywords
Sensing and Imaging Agents for Cyclooxygenase Enzyme
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202400636
Abstract: In this concept, we present a comprehensive study on the development and application of COX‐2‐specific fluorescent probes for cancer imaging and diagnosis. To target cancer cells and measuring cancer‐related activities in specific organelles quickly and… read more here.
Keywords: cyclooxygenase enzyme; cancer; cox; imaging agents ... See more keywords
Aminonaphthalimide hybrids of mitoxantrone and amonafide as anticancer and fluorescent cellular imaging agents.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103287
Abstract: Novel water-soluble 4-aminonaphthalimides were synthesised and their cellular fluorescent imaging, cytotoxicity and ability to induced apoptosis evaluated. The lead compound 1 was designed from the cross-fertilisation of the basic hydrophilic amino pharmacophore of mitoxantrone, and… read more here.
Keywords: cellular imaging; anticancer fluorescent; microscopy; fluorescent ... See more keywords
Synthesis and evaluation of 2-(2'-((dimethylamino)methyl)-4'-(2-fluoroethoxy-substituted)phenylthio)benzenamine derivatives as potential positron emission tomography imaging agents for serotonin transporters.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103654
Abstract: A series of diphenylsulfide derivatives with various substitutions at the 4-position on phenyl ring A and different lengths of the 2-fluoroethoxy-substituted side-chain at the 4'-position on ring B were synthesized and evaluated as potential positron… read more here.
Keywords: potential positron; fluoroethoxy substituted; imaging agents; positron emission ... See more keywords
FAP-Targeted Fluorescent Imaging Agents to Study Cancer-Associated Fibroblasts In Vivo
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DOI: 10.1021/acs.bioconjchem.4c00426
Abstract: Cancer-associated fibroblasts (CAFs) expressing fibroblast activation protein alpha (FAP) are abundant in tumor microenvironments and represent an emerging target for PET cancer imaging. While different quinolone-based small molecule agents have been developed for whole-body imaging,… read more here.
Keywords: cancer; imaging agents; associated fibroblasts; cancer associated ... See more keywords
Highly fluorinated metal complexes as dual 19F and PARACEST imaging agents.
Sign Up to like & getrecommendations! Published in 2019 at "Dalton transactions"
DOI: 10.1039/c9dt01852b
Abstract: We reported a set of water-soluble transition metal complexes that can serve as both 19F and PARACEST magnetic resonance imaging agents. The high number of equivalent fluorine atoms and the paramagnetic effect of metals offer… read more here.
Keywords: imaging agents; metal complexes; fluorinated metal; 19f paracest ... See more keywords
Multiscale imaging of therapeutic anti-PD-L1 antibody localization using molecularly defined imaging agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-022-01272-5
Abstract: Background While immune checkpoint inhibitors such as anti-PD-L1 antibodies have revolutionized cancer treatment, only subgroups of patients show durable responses. Insight in the relation between clinical response, PD-L1 expression and intratumoral localization of PD-L1 therapeutics… read more here.
Keywords: molecularly defined; tumor; imaging agents; localization ... See more keywords
Development and Clinical Application of Positron Emission Tomography Imaging Agents for Monoamine Oxidase B
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.773404
Abstract: Monoamine oxidase B (MAO-B) is a high-density protein in the brain mainly found on outer mitochondrial membranes, primarily in astroglia, but additionally in serotonergic neurons and in the substantia nigra in the midbrain. It is… read more here.
Keywords: mao; positron emission; emission tomography; monoamine oxidase ... See more keywords
Single-Domain Antibodies as Therapeutic and Imaging Agents for the Treatment of CNS Diseases
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DOI: 10.3390/antib8020027
Abstract: Antibodies have become one of the most successful therapeutics for a number of oncology and inflammatory diseases. So far, central nervous system (CNS) indications have missed out on the antibody revolution, while they remain ‘hidden’… read more here.
Keywords: cns diseases; antibody; single domain; domain antibodies ... See more keywords
A Series of PSMA-Targeted Near-Infrared Fluorescent Imaging Agents
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DOI: 10.3390/biom12030405
Abstract: We have synthesized a series of 10 new, PSMA-targeted, near-infrared imaging agents intended for use in vivo for fluorescence-guided surgery (FGS). Compounds were synthesized from the commercially available amine-reactive active NHS ester of DyLight800. We… read more here.
Keywords: targeted near; imaging agents; series; psma targeted ... See more keywords
Clinical Evaluation of Nuclear Imaging Agents in Breast Cancer
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DOI: 10.3390/cancers14092103
Abstract: Simple Summary Breast cancer is currently the most common type of diagnosed cancer worldwide. Noninvasive imaging of therapeutic targets or biomarkers for breast cancer has the potential to contribute to precision medicine, where targeted therapy… read more here.
Keywords: therapy; breast cancer; medicine; cancer ... See more keywords