Tissue sample preparations for preclinical research determined by molecular imaging mass spectrometry using MALDI.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of separation science"
DOI: 10.1002/jssc.202100578
Abstract: Matrix-assisted laser desorption/ionization - imaging mass spectrometry is an alternative tool, which can be implemented in order to obtain and visualize the "omic" signature of tissue samples. Its application to clinical study enables simultaneous imaging-based… read more here.
Keywords: mass spectrometry; spectrometry; imaging mass; research ... See more keywords
High-Fidelity Quantification of Cell Cycle Activity with Multi-Isotope Imaging Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0668-1_19
Abstract: The quantification of cell cycle activity is a prerequisite to defining the dynamics and scope of organ development or regeneration. Multi-isotope imaging mass spectrometry (MIMS) merges stable isotope tracers with an imaging mass spectrometry platform… read more here.
Keywords: quantification cell; imaging mass; mass spectrometry; isotope ... See more keywords
Imaging mass spectrometry-guided fast identification of antifungal secondary metabolites from Penicillium polonicum
Sign Up to like & getrecommendations! Published in 2018 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-018-9218-8
Abstract: The discovery of antibiotics from microorganisms using classic bioactivity screens suffers from heavy labor and high re-discovery rate. Recently, largely uncovered biosynthetic potentials were unveiled by new approaches, such as genetic manipulation of “silent” biosynthetic… read more here.
Keywords: mass spectrometry; imaging mass; identification; penicillium polonicum ... See more keywords
Assessing the Potential of Metal-Assisted Imaging Mass Spectrometry in Cancer Research.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2016.11.003
Abstract: In the last decade, imaging mass spectrometry (IMS) has been the primary tool for biomolecular imaging. While it is possible to map a wide range of biomolecules using matrix-assisted laser desorption/ionization IMS ranging from high-molecular-weight… read more here.
Keywords: cancer; imaging mass; cancer research; mass spectrometry ... See more keywords
Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.133
Abstract: OBJECT The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has… read more here.
Keywords: imaging mass; mass spectroscopy; intracranial aneurysms; wall ... See more keywords
Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109919
Abstract: SUMMARY Type 2 diabetes mellitus (T2D) is a chronic age-related disorder characterized by hyperglycemia due to the failure of pancreatic beta cells to compensate for increased insulin demand. Despite decades of research, the pathogenic mechanisms… read more here.
Keywords: imaging mass; type diabetes; cell; mass cytometry ... See more keywords
Imaging mass spectrometry tackles interfacial challenges in electrochemistry
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Electrochemistry"
DOI: 10.1016/j.coelec.2017.10.025
Abstract: Summary Electrochemistry has played a significant role in many research fields. Owing to its sensitivity and selectivity, in situ electroanalysis has been widely used as a fast and economical means for achieving outstanding results. Although… read more here.
Keywords: imaging mass; electrochemistry imaging; electrochemistry; mass spectrometry ... See more keywords
Discovering new lipidomic features using cell type specific fluorophore expression to provide spatial and biological specificity in a multimodal workflow with MALDI Imaging Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c00446
Abstract: Identifying the spatial distributions of biomolecules in tissue is crucial for understanding integrated function. Imaging Mass Spectrometry (IMS) allows simultaneous mapping of thousands of biosynthetic products such as lipids but has needed a means of… read more here.
Keywords: imaging mass; cell type; mass spectrometry;
Development of "Laser Ablation Direct Analysis in Real Time Imaging" Mass Spectrometry: Application to Spatial Distribution Mapping of Metabolites Along the Biosynthetic Cascade Leading to Synthesis of Atropine and Scopolamine in Plant Tissue.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.6b04137
Abstract: Methods for the accomplishment of small-molecule imaging by mass spectrometry are challenged by the need for sample pretreatment steps, such as cryo-sectioning, dehydration, chemical fixation, or application of a matrix or solvent, that must be… read more here.
Keywords: mass spectrometry; imaging mass; mass; time ... See more keywords
Influence of the Cation Adducts in the Analysis of Matrix-Assisted Laser Desorption Ionization Imaging Mass Spectrometry Data from Injury Models of Rat Spinal Cord.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b02650
Abstract: Imaging mass spectrometry (IMS) is quickly becoming a technique of reference to visualize the lipid distribution in tissue sections. Still, many questions remain open, and data analysis has to be optimized to avoid interpretation pitfalls.… read more here.
Keywords: mass spectrometry; imaging mass; cord; injury ... See more keywords
Next Generation Histology-Directed Imaging Mass Spectrometry Driven by Autofluorescence Microscopy.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b02885
Abstract: Histology-directed imaging mass spectrometry (IMS) is a spatially targeted IMS acquisition method informed by expert annotation that provides rapid molecular characterization of select tissue structures. The expert annotations are usually determined on digital whole slide… read more here.
Keywords: microscopy; directed imaging; imaging mass; histology directed ... See more keywords