Direct Imaging of Protein‐Specific Methylation in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800787
Abstract: Abundant post‐translational modification through methylation alters the function, stability, and/or localization of a protein. Malfunctions in post‐translational modification are associated with severe diseases. To unravel protein methylation sites and their biological functions, chemical methylation reporters… read more here.
Keywords: protein; imaging protein; methylation; specific methylation ... See more keywords
Fluorescent Probes for Imaging Protein Disulfides in Live Organisms.
Sign Up to like & getrecommendations! Published in 2021 at "ACS sensors"
DOI: 10.1021/acssensors.1c00049
Abstract: Cellular redox homeostasis is predominantly controlled by the ratio of thiols and disulfides, and reversible thiol-disulfide exchange reactions are fundamental of the biological redox regulation. However, due to the dynamic exchanges of thiols and disulfides,… read more here.
Keywords: imaging protein; live organisms; protein disulfides; probes imaging ... See more keywords
Imaging Protein Misfolding in the Brain Using β-Sheet Ligands
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.00585
Abstract: Neurodegenerative diseases characterized by pathological protein accumulation in cells are termed “proteinopathies.” Although various protein aggregates share cross-β-sheet structures, actual conformations vary among each type of protein deposit. Recent progress in the development of radiotracers… read more here.
Keywords: protein; protein misfolding; imaging protein; pet tracers ... See more keywords