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Published in 2022 at "Molecular oncology"
DOI: 10.1002/1878-0261.13199
Abstract: Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumors (GISTs). While acquired on-target mutations of mast/stem cell growth factor receptor (KIT) kinase is the major resistance mechanism, activation of alternative…
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Keywords:
imatinib;
stromal tumors;
kit mutations;
resistance ... See more keywords
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Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13270
Abstract: The oncogenic role of ephrin type‐B receptor 4 (EPHB4) has been reported in many types of tumors, including chronic myeloid leukemia (CML). Here, we found that CML patients have a higher EPHB4 expression level than…
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Keywords:
imatinib;
growth;
ephrin type;
vandetanib ... See more keywords
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Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.11992
Abstract: The activation of hepatic stellate cells is the primary function of facilitating liver fibrosis. Interfering with the coordinators of different signaling pathways in activated hepatic stellate cells (aHSCs) could be a potential approach in ameliorating…
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Keywords:
imatinib;
liver fibrosis;
mir 124;
stat3 ... See more keywords
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Published in 2021 at "Journal of surgical oncology"
DOI: 10.1002/jso.26628
Abstract: BACKGROUND AND OBJECTIVES This study aimed to characterize the efficacy of neoadjuvant imatinib in rectal gastrointestinal stromal tumors (GISTs) and the prognostic characteristics of patients after surgery. METHODS Patients with rectal GISTs who received neoadjuvant…
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Keywords:
rectal gastrointestinal;
gastrointestinal stromal;
neoadjuvant imatinib;
therapy ... See more keywords
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Published in 2021 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-021-03230-w
Abstract: Schistosoma mansoni is a parasitic flatworm causing schistosomiasis, an infectious disease affecting several hundred million people worldwide. Schistosomes live dioeciously, and upon pairing with the male, the female starts massive egg production, which causes pathology.…
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Keywords:
drug imaging;
drug;
smaldi msi;
schistosoma mansoni ... See more keywords
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Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02888-y
Abstract: Purpose The aim of this study was to ascertain whether the absolute bioavailability of oral imatinib (Glivec®) during steady state plasma pharmacokinetics in cancer patients could be determined through a concomitant intravenous administration of a…
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Keywords:
stable isotopically;
absolute bioavailability;
bioavailability oral;
imatinib ... See more keywords
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Published in 2017 at "Annals of Hematology"
DOI: 10.1007/s00277-017-3021-y
Abstract: The relative merits of reduced intensity hematopoietic stem cell transplantation (RIST) for chronic myeloid leukemia (CML) in the first chronic phase (CP) in imatinib era have not been evaluated. The study was designed to compare…
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Keywords:
treatment;
rist;
reduced intensity;
hematopoietic stem ... See more keywords
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Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-02894-3
Abstract: BackgroundIn the phase 3 BFORE trial (NCT02130557), treatment with bosutinib resulted in a significantly higher major molecular response rate at 12 months versus imatinib in the modified intent-to-treat (mITT) population of patients with newly diagnosed chronic…
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Keywords:
phase;
newly diagnosed;
treatment;
bfore trial ... See more keywords
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Published in 2019 at "International Journal of Hematology"
DOI: 10.1007/s12185-019-02596-z
Abstract: Knowledge of the toxicity profile of long-term treatment with imatinib is limited. In the present study, we sought to evaluate renal function and hemoglobin levels during long-term imatinib treatment. Eighty-two patients with chronic myelogenous leukemia…
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Keywords:
renal dysfunction;
long term;
term imatinib;
hemoglobin levels ... See more keywords
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Published in 2017 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-017-1108-y
Abstract: AbstractMagnetic solid-phase extraction based on Fe3O4/graphene oxide nanocomposites was investigated for the separation, preconcentration and determination of imatinib and doxorubicin in aqueous solutions. Synthesis of Fe3O4/graphene oxide was characterized by transmission electron microscopy, energy-dispersive X-ray…
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Keywords:
graphene oxide;
extraction;
fe3o4 graphene;
imatinib doxorubicin ... See more keywords
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Published in 2017 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2017.03.034
Abstract: The development of an immunoassay for a low-molecular-weight drug first requires the identification of specific antibodies that do not cross-react with the drug's metabolites. If two antibodies can simultaneously recognize the entire structure of the…
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Keywords:
anti imatinib;
sandwich elisa;
drug;
imatinib antibodies ... See more keywords