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   Articles with "imatinib" as a keyword



Nintedanib overcomes drug resistance from upregulation of FGFR signaling and imatinib-induced KIT mutations in gastrointestinal stromal tumors.

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recommendations! Published in 2022 at "Molecular oncology"

DOI: 10.1002/1878-0261.13199

Abstract: Drug resistance remains a major challenge in the clinical treatment of gastrointestinal stromal tumors (GISTs). While acquired on-target mutations of mast/stem cell growth factor receptor (KIT) kinase is the major resistance mechanism, activation of alternative… read more here.

Keywords: imatinib; stromal tumors; kit mutations; resistance ... See more keywords

Vandetanib drives growth arrest and promotes sensitivity to imatinib in chronic myeloid leukemia by targeting ephrin type‐B receptor 4

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recommendations! Published in 2022 at "Molecular Oncology"

DOI: 10.1002/1878-0261.13270

Abstract: The oncogenic role of ephrin type‐B receptor 4 (EPHB4) has been reported in many types of tumors, including chronic myeloid leukemia (CML). Here, we found that CML patients have a higher EPHB4 expression level than… read more here.

Keywords: imatinib; growth; ephrin type; vandetanib ... See more keywords

Imatinib suppresses activation of hepatic stellate cells by targeting STAT3/IL‐6 pathway through miR‐124

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recommendations! Published in 2023 at "Cell Biology International"

DOI: 10.1002/cbin.11992

Abstract: The activation of hepatic stellate cells is the primary function of facilitating liver fibrosis. Interfering with the coordinators of different signaling pathways in activated hepatic stellate cells (aHSCs) could be a potential approach in ameliorating… read more here.

Keywords: imatinib; liver fibrosis; mir 124; stat3 ... See more keywords

Synthesis of chitosan polyethylene glycol antibody complex for delivery of Imatinib in lung cancer cell lines

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recommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"

DOI: 10.1002/jbt.23787

Abstract: Lung cancer is known as the most common cancer. Although the Ramucirumab antibody is a second‐line treatment for lung cancer, the high interstitial fluid pressure limits the antibody's performance. In this way, Imatinib is a… read more here.

Keywords: imatinib; cancer; lung cancer; cell ... See more keywords
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The effect of neoadjuvant imatinib therapy on outcome and survival in rectal gastrointestinal stromal tumors: A multiinstitutional study.

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recommendations! Published in 2021 at "Journal of surgical oncology"

DOI: 10.1002/jso.26628

Abstract: BACKGROUND AND OBJECTIVES This study aimed to characterize the efficacy of neoadjuvant imatinib in rectal gastrointestinal stromal tumors (GISTs) and the prognostic characteristics of patients after surgery. METHODS Patients with rectal GISTs who received neoadjuvant… read more here.

Keywords: rectal gastrointestinal; gastrointestinal stromal; neoadjuvant imatinib; therapy ... See more keywords

High-resolution AP-SMALDI MSI as a tool for drug imaging in Schistosoma mansoni

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recommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-021-03230-w

Abstract: Schistosoma mansoni is a parasitic flatworm causing schistosomiasis, an infectious disease affecting several hundred million people worldwide. Schistosomes live dioeciously, and upon pairing with the male, the female starts massive egg production, which causes pathology.… read more here.

Keywords: drug imaging; drug; smaldi msi; schistosoma mansoni ... See more keywords
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Determination of the absolute bioavailability of oral imatinib using a stable isotopically labeled intravenous imatinib-d8 microdose

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recommendations! Published in 2020 at "European Journal of Clinical Pharmacology"

DOI: 10.1007/s00228-020-02888-y

Abstract: Purpose The aim of this study was to ascertain whether the absolute bioavailability of oral imatinib (Glivec®) during steady state plasma pharmacokinetics in cancer patients could be determined through a concomitant intravenous administration of a… read more here.

Keywords: stable isotopically; absolute bioavailability; bioavailability oral; imatinib ... See more keywords

Reduced-intensity allogeneic hematopoietic stem cell transplantation combined with imatinib has comparable event-free survival and overall survival to long-term imatinib treatment in young patients with chronic myeloid leukemia

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recommendations! Published in 2017 at "Annals of Hematology"

DOI: 10.1007/s00277-017-3021-y

Abstract: The relative merits of reduced intensity hematopoietic stem cell transplantation (RIST) for chronic myeloid leukemia (CML) in the first chronic phase (CP) in imatinib era have not been evaluated. The study was designed to compare… read more here.

Keywords: treatment; rist; reduced intensity; hematopoietic stem ... See more keywords

Patient-reported outcomes in the phase 3 BFORE trial of bosutinib versus imatinib for newly diagnosed chronic phase chronic myeloid leukemia

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recommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-019-02894-3

Abstract: BackgroundIn the phase 3 BFORE trial (NCT02130557), treatment with bosutinib resulted in a significantly higher major molecular response rate at 12 months versus imatinib in the modified intent-to-treat (mITT) population of patients with newly diagnosed chronic… read more here.

Keywords: phase; newly diagnosed; treatment; bfore trial ... See more keywords

Overall survival of patients with KIT-mutant metastatic GIST in the era of multiple kinase inhibitor availability

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recommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-024-05965-2

Abstract: The prognosis of patients with metastatic GIST and imatinib-sensitive primary mutations has significantly improved. However, limited data are available to inform patients about outcomes across different lines of treatment. This retrospective analysis aims to evaluate… read more here.

Keywords: imatinib; treatment; patients metastatic; metastatic gist ... See more keywords

Renal dysfunction and anemia associated with long-term imatinib treatment in patients with chronic myelogenous leukemia

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recommendations! Published in 2019 at "International Journal of Hematology"

DOI: 10.1007/s12185-019-02596-z

Abstract: Knowledge of the toxicity profile of long-term treatment with imatinib is limited. In the present study, we sought to evaluate renal function and hemoglobin levels during long-term imatinib treatment. Eighty-two patients with chronic myelogenous leukemia… read more here.

Keywords: renal dysfunction; long term; term imatinib; hemoglobin levels ... See more keywords