Imatinib induces autophagy via upregulating XIAP in GIST882 cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.096
Abstract: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms originating from the gastrointestinal tract with gain of function mutations in receptor tyrosine kinases KIT or platelet-derived growth factor receptor A (PDGFRA). The main effective… read more here.
Keywords: imatinib induced; xiap; resistance; gist882 cells ... See more keywords
IFNγ directly counteracts imatinib-induced apoptosis of primary human CD34+ CML stem/progenitor cells potentially through the upregulation of multiple key survival factors
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2109861
Abstract: ABSTRACT Tyrosine kinase inhibitors (TKIs) have dramatically improved the survival in chronic myeloid leukemia (CML), but residual disease typically persists even after prolonged treatment. Several lines of evidence suggest that TKIs administered to CML patients… read more here.
Keywords: stem progenitor; cml; ifn; imatinib induced ... See more keywords
Imatinib‐induced generalized vitiligo
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18096
Abstract: A 60yearold man without any comorbidities was diagnosed with chronic phase chronic myeloid leukaemia (Sokal lowrisk) in October 2020. He was started on oral imatinib 400 mg once a day, with which he achieved a… read more here.
Keywords: imatinib; induced generalized; generalized vitiligo; imatinib induced ... See more keywords
Imatinib Regulates miR-483-3p and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal Tumors
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms221910600
Abstract: Metabolic adaptation to increased oxidative phosphorylation (OXPHOS) has been found in gastrointestinal stromal tumor (GIST) upon imatinib treatment. However, the underlying mechanism of imatinib-induced OXPHOS is unknown. Discovering molecules that mediate imatinib-induced OXPHOS may lead… read more here.
Keywords: mitochondrial respiratory; imatinib induced; gastrointestinal stromal; gist ... See more keywords