Overcoming imatinib resistance in chronic myelogenous leukemia cells using non-cytotoxic cell death modulators.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111748
Abstract: Recent studies examined the possibility to overcome imatinib resistance in chronic myeloid leukemia (CML) patients by combination therapy with peroxisome proliferator-activated receptor gamma (PPARĪ³) ligands. Pioglitazone, a full PPARĪ³ agonist, improved the survival of patients… read more here.
Keywords: ppar; resistance chronic; imatinib resistance; resistance ... See more keywords
Downregulation of miR-451 in Tunisian chronic myeloid leukemia patients: potential implication in imatinib resistance
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DOI: 10.1080/10245332.2016.1252020
Abstract: ABSTRACT Objectives: Resistance to imatinib has been recognized as a major challenge for the treatment of chronic myeloid leukemia (CML). Aberrant expression of miR-451 has been reported to participate in anticancer drug resistance. However, the… read more here.
Keywords: cml; imatinib resistance; resistance; chronic myeloid ... See more keywords
The Interrelationship Between Fyn And Mir-128/193a-5p/494 In Imatinib Resistance In Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520622666220601093452
Abstract: Background C-KIT is a receptor tyrosine kinase with oncogenic properties overexpressed in PCa cases. Through the use of an alternative promoter, a truncated c-KIT protein (tr-KIT) of 30-50 kDa is generated, lacking the extracellular and… read more here.
Keywords: 128 193a; kit; imatinib resistance; 193a 494 ... See more keywords
MiRNA-409-5p dysregulation promotes imatinib resistance and disease progression in children with chronic myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201910_19159
Abstract: OBJECTIVE To elucidate the role of miRNA-409-5p in the pathogenesis of child chronic myeloid leukemia (CML) and its potential mechanism. PATIENTS AND METHODS Expression levels of miRNA-409-5p and NUP43 in peripheral blood of CML children… read more here.
Keywords: cml; imatinib resistance; expression; progression ... See more keywords
Rare c-KIT c.1926delA and c.1936T>G Mutations in Exon 13 Define Imatinib Resistance in Gastrointestinal Stromal Tumors and Melanoma Patients: Case Reports and Cell Experiments
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.730213
Abstract: Background: Target therapies play more and more important roles in gastrointestinal stromal tumors (GISTs) and melanoma with the advancement of clinical drugs that overcome the resistance caused by gene mutations. c-KIT gene mutations account for… read more here.
Keywords: cell experiments; imatinib; stromal tumors; resistance ... See more keywords
Circ-CCS enhances autophagy during imatinib resistance of gastrointestinal stromal tumor by regulating miR-197-3p/ATG10 signaling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/jcrt.jcrt_625_22
Abstract: Context: Drug resistance in gastrointestinal stromal tumors (GISTs) is connected with autophagy activation. Accumulating data demonstrates the critical role of circular RNAs (circRNAs) dysregulation in this development. Aim: To explore the possible function of hsa_circ_0092306… read more here.
Keywords: gist; ccs; mir 197; imatinib resistance ... See more keywords