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Published in 2021 at "Surgery Today"
DOI: 10.1007/s00595-021-02241-5
Abstract: Imatinib is the standard treatment for unresectable and metastatic GIST. In the late stages, patients undergoing imatinib show drug resistance. Surgical intervention has been occasionally performed for resistant lesions. However, the clinical significance of such…
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Keywords:
intervention;
imatinib resistant;
surgical intervention;
resistance ... See more keywords
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Published in 2022 at "Scandinavian Journal of Gastroenterology"
DOI: 10.1080/00365521.2022.2087475
Abstract: Abstract A gastrointestinal stromal tumor (GIST) is mostly driven by the auto-activated, mutant KIT receptor tyrosine kinase gene or by the platelet-derived growth factor receptor alpha. Inhibition of KIT-signaling is the primary molecular target therapy…
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Keywords:
gist;
stromal tumor;
imatinib resistant;
model ... See more keywords
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Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2189097
Abstract: Abstract The design of kinase inhibitors targeting the oncogenic kinase BCR-ABL constitutes a promising paradigm for treating chronic myeloid leukaemia (CML). Nevertheless, the efficacy of imatinib, the first FDA-approved targeted therapy for CML, is curbed…
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Keywords:
imatinib resistant;
activity;
bcr;
bcr abl ... See more keywords
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Published in 2022 at "Anti-Cancer Drugs"
DOI: 10.1097/cad.0000000000001421
Abstract: Although imatinib has revolutionized the treatment of chronic myeloid leukemia (CML), s develop resistance to imatinib when progress to blast phase and relapse. Myricetin, a flavonoid compound found in natural plants, has multiple biological functions.…
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Keywords:
myeloid leukemia;
chronic myeloid;
imatinib;
myricetin ... See more keywords
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Published in 2022 at "Metabolites"
DOI: 10.3390/metabo13010058
Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative haematological malignancy characterized by constitutive activation of BCR-ABL1 tyrosine kinase in the majority of patients. BCR-ABL1 expression activates signaling pathways involved in cell proliferation and survival. Current treatment…
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Keywords:
imatinib sensitive;
cell;
imatinib;
proliferation ... See more keywords
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Published in 2023 at "Journal of Cancer"
DOI: 10.7150/jca.83219
Abstract: Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. T315I mutated BCR-ABL is the main cause of the resistance mediated by imatinib and second generation…
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Keywords:
abl t315i;
imatinib resistant;
bcr abl;
differentiation ... See more keywords