IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis
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DOI: 10.1038/s41598-018-35701-z
Abstract: The anti-tuberculosis (TB) agent IMB-T130 was speculated to be a multi-target compound. In this research, we found that IMB-T130 inhibits the catalytic activity of Mycobacterium tuberculosis 3-dehydroquinate synthase (MtDHQS), the enzyme in the second step… read more here.
Keywords: dehydroquinate synthase; imb; imb t130; mycobacterium tuberculosis ... See more keywords