POS1426 PATIENTS WITH IMMUNE MEDIATED INFLAMMATORY DISEASES ARE OVERREPRESENTED IN LOW- FREQUENCY VIRAL SYMPTOM CLUSTERS
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.1598
Abstract: Viral respiratory infections are common in the general population and result in a spectrum of outcomes ranging from effective viral clearance with no symptoms, to a maladaptive immune response that can result in severe symptomatic… read more here.
Keywords: imid; cluster; frequency; symptom clusters ... See more keywords
IKZF1/3 and CRL4CRBN E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Haematologica"
DOI: 10.3324/haematol.2019.217943
Abstract: Cereblon (CRBN), a target of immunomodulatory drugs (IMiD), forms the CRL4 E3 ubiquitin ligase (CRL4) complex with DDB1, CUL4B and ROC1. Under the influence of IMiD, CRL4 polyubiquitinates and thus depletes the transcription factors IKZF1… read more here.
Keywords: multiple myeloma; ubiquitin ligase; imid; immunomodulatory drugs ... See more keywords