Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2‐b]pyrazole‐7‐carboxamides
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DOI: 10.1002/ardp.201800062
Abstract: The synthesis and in vitro cytotoxic characteristics of new imidazo[1,2‐b]pyrazole‐7‐carboxamides were investigated. Following a hit‐to‐lead optimization exploiting 2D and 3D cultures of MCF‐7 human breast, 4T1 mammary gland, and HL‐60 human promyelocytic leukemia cancer cell… read more here.
Keywords: pyrazole carboxamides; cytotoxic characterization; imidazo pyrazole; sar ... See more keywords
A Proteomics Approach Identifies RREB1 as a Crucial Molecular Target of Imidazo–Pyrazole Treatment in SKMEL-28 Melanoma Cells
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DOI: 10.3390/ijms25126760
Abstract: Cutaneous melanoma is the most dangerous and deadly form of human skin malignancy. Despite its rarity, it accounts for a staggering 80% of deaths attributed to cutaneous cancers overall. Moreover, its final stages often exhibit… read more here.
Keywords: proteomics approach; melanoma; imidazo pyrazole; approach identifies ... See more keywords