Hybrid imidazo[1,2‐a]pyridine analogs as potent ATX inhibitors with concrete in vivo antifibrosis effect
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200171
Abstract: In recent years, small‐molecule inhibitors targeting the autotaxin (ATX)/lysophosphatidic acid axis gradually brought excellent disease management benefits. Herein, a series of imidazo[1,2‐a]pyridine compounds (1–11) were designed as ATX inhibitors through a hybrid strategy by combining… read more here.
Keywords: analogs potent; hybrid imidazo; imidazo pyridine; atx inhibitors ... See more keywords
Imidazo[1,2‐a]pyridine Derivatives as AMPK Activators: Synthesis, Structure–Activity Relationships, and Regulation of Reactive Oxygen Species in Renal Fibroblasts
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200696
Abstract: Adenosine 5′‐monophosphate activated protein kinase (AMPK) has emerged as a promising target for the discovery of drugs to treat diabetic nephropathy (DN). Herein, a series of imidazo[1,2‐a]pyridines were designed and synthesized. Among them, the active… read more here.
Keywords: reactive oxygen; imidazo pyridine; oxygen species; pyridine derivatives ... See more keywords
A large stokes shift fluorescent probe for sensing of thiophenols based on imidazo[1,5-α]pyridine in both aqueous medium and living cells.
Sign Up to like & getrecommendations! Published in 2017 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2017.09.016
Abstract: An imidazo [1,5-α]pyridine-based fluorescent probe MIPY-DNP with a large Stokes shift (173 nm) for the sensing of thiophenols in aqueous medium has been developed. This probe with 2,4-dinitrophenyl ether as a highly thiophenol-selective group was constructed… read more here.
Keywords: fluorescent probe; large stokes; probe; imidazo pyridine ... See more keywords
A FRET ratiometric fluorescent probe for detection of Hg2+ based on an imidazo[1,2-a]pyridine-rhodamine system.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.05.043
Abstract: A novel imidazo[1,2-a]pyridine-rhodamine ratiometric fluorescent probe IP-Hg for Hg2+ based on a fluorescence resonance energy transfer mechanism has been developed. The probe has been proved to show high sensitivity and high selectivity toward Hg2+. Furthermore,… read more here.
Keywords: hg2; imidazo pyridine; fluorescent probe; ratiometric fluorescent ... See more keywords
Hypervalent iodine(III) catalyzed rapid and efficient access to benzimidazoles, benzothiazoles and quinoxalines: Biological evaluation of some new benzimidazole-imidazo[1,2-a]pyridine conjugates
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2017.02.007
Abstract: Abstract A rapid, simple and highly efficient method for the synthesis of a variety of 2-aryl-benzimidazoles, 2-aryl-benzothiazoles and quinoxalines has been developed using Koser’s reagent [PhI(OH)OTs] as catalyst. The present work highlights the potential of… read more here.
Keywords: pyridine conjugates; imidazo pyridine; benzothiazoles quinoxalines; benzimidazole imidazo ... See more keywords
Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105590
Abstract: Aiming to develop novel allosteric autotaxin (ATX) inhibitors, hybrid strategy was utilized by assembling the benzyl carbamate fragment in PF-8380 onto the imidazo[1,2-a]pyridine skeleton of GLPG-1690. The piperazine moiety in GLPG-1690 was replaced with phenyl… read more here.
Keywords: imidazo pyridine; mice lung; glpg 1690; vivo ... See more keywords
Chemical, electrochemical, quantum, and surface analysis evaluation on the inhibition performance of novel imidazo[4,5-b] pyridine derivatives against mild steel corrosion
Sign Up to like & getrecommendations! Published in 2021 at "Corrosion Science"
DOI: 10.1016/j.corsci.2021.109621
Abstract: Abstract In this article, we evaluated the inhibitory performance of imidazo[4,5-b] pyridine derivatives namely, 6-bromo-2-(4-chlorophenyl)-3-(prop-2-yn-1-yl)-3H-imidazo[4,5-b]pyridine(SB9a) and 6-bromo-2-(4-chlorophenyl)-3-decyl-3H-imidazo[4,5-b]pyridine (SB14a) against mild steel (MS) corrosion in 1 M HCl using weight Loss from 303 to 333 K,… read more here.
Keywords: imidazo pyridine; pyridine derivatives; performance; spectroscopy ... See more keywords
Regioselective N–alkylation of 2– (3,4–dimethoxyphenyl)imidazo[4,5–b] and [4,5–c]pyridine oxide derivatives : Synthesis and structure elucidation by NMR
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.07.058
Abstract: Abstract Imidazopyridines can exist in several tautomeric forms such as benzimidazole or purine condensed systems. Regioselectivities were determined for N-alkylations of 2-(3,4-dimethoxyphenyl)- imidazopyridines and their 4 and 5-oxides (2–4, 13, 14) with n-butyl and 4-fluorobenzyl… read more here.
Keywords: imidazo pyridine; regioselective alkylation; pyridine oxide; structure ... See more keywords
Novel amide derivatives containing an imidazo[1,2-a]pyridine moiety: Design, synthesis as potential nematicidal and antibacterial agents.
Sign Up to like & getrecommendations! Published in 2021 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2021.104857
Abstract: To discover new nematicides, a series of novel amide derivatives containing an imidazo[1,2-a]pyridine moeity were designed and synthesized. Among the title compounds, compounds 3 and 27 exhibited good nematicidal activities against Aphelenchoides besseyi (rice white-tip… read more here.
Keywords: amide derivatives; novel amide; imidazo pyridine; derivatives containing ... See more keywords
Contextualizing yellow light-emitting electrochemical cells based on a blue-emitting imidazo-pyridine emitter
Sign Up to like & getrecommendations! Published in 2018 at "Polyhedron"
DOI: 10.1016/j.poly.2017.11.048
Abstract: Abstract This work provides the synthesis, structural characterization, electrochemical and photophysical features, as well as the application in light-emitting electrochemical cells (LECs) of a novel small molecule belonging to the pyridilimidazo[1,5-a]pyridine family, namely 3-(2-methoxyphenyl)-5-methyl-1-(6-methylpyridin-2-yl)H-imidazo[1,5-a]pyridine (Me-impy).… read more here.
Keywords: imidazo pyridine; electrochemical cells; light emitting; emitting electrochemical ... See more keywords
Imidazo[1,5-α]pyridine-derived fluorescent turn-on probe for cellular thiols imaging with a large Stokes shift
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.05.068
Abstract: Abstract We presented the design, synthesis and preliminary evaluation of the 2,4-dinitrobenzenesulfonate (DNBS) of imidazo[1,5- α ]pyridine derivative, NIPY-DNBS , as a turn-on fluorescent probe for the detection of thiols in aqueous solution. The reaction… read more here.
Keywords: probe; large stokes; imidazo pyridine; nipy dnbs ... See more keywords